Measurement of the Raman spectra and hygroscopicity of four pharmaceutical aerosols as they travel from pressurised metered dose inhalers (pMDI) to a model lung

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Title: Measurement of the Raman spectra and hygroscopicity of four pharmaceutical aerosols as they travel from pressurised metered dose inhalers (pMDI) to a model lung
Authors: Davidson, N
Tong, H-J
Kalberer, M
Seville, PC
Ward, AD
Kuimova, MK
Pope, FD
Item Type: Journal Article
Abstract: Particle inhalation is an effective and rapid delivery method for a variety of pharmaceuticals, particularly bronchodilation drugs used for treating asthma and COPD. Conditions of relative humidity and temperature inside the lungs are generally very different from the outside ambient air, with the lung typically being warmer and more humid. Changes in humidity, from inhaler to lung, can cause hygroscopic phase transitions and particle growth. Increasing particle size and mass can negatively affect particle deposition within the lung leading to inefficient treatment, while deliquescence prior to impaction is liable to accelerate drug uptake. To better understand the hygroscopic properties of four pharmaceutical aerosol particles; pharmaceutical particles from four commercially available pressurised metered dose inhalers (pMDIs) were stably captured in an optical trap, and their composition was examined online via Raman spectroscopy. Micron-sized particles of salbutamol sulfate, salmeterol xinafoate, fluticasone propionate and ciclesonide were levitated and examined over a range of relative humidity values inside a chamber designed to mimic conditions within the respiratory tract. The effect of temperature upon hygroscopicity was also investigated for salbutamol sulfate particles. Salbutamol sulfate was found to have significant hygroscopicity, salmeterol xinafoate showed some hygroscopic interactions, whilst fluticasone propionate and ciclesonide revealed no observable hygroscopicity. Thermodynamic and structural modelling is used to explain the observed experimental results.
Issue Date: 31-Jan-2017
Date of Acceptance: 25-Jan-2017
ISSN: 0378-5173
Publisher: ELSEVIER
Start Page: 59
End Page: 69
Volume: 520
Issue: 1-2
Copyright Statement: © 2017 Elsevier B.V. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Sponsor/Funder: Engineering & Physical Science Research Council (EPSRC)
Funder's Grant Number: EP/I003983/1
Keywords: Science & Technology
Life Sciences & Biomedicine
Pharmacology & Pharmacy
Optical trapping
Laser tweezers
Suspended particle
Ciclesonide (PubChem CID: 6918155)
Fluticasone propionate (PubChem CID: 444036)
Salbutamol sulfate (PubChem CID: 39859)
Salmeterol xinafoate (PubChem CID: 56801)
1115 Pharmacology And Pharmaceutical Sciences
Publication Status: Published
Appears in Collections:Chemistry
Faculty of Natural Sciences

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