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Externally induced frontoparietal synchronization modulates network dynamics and enhances working memory performance.

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Title: Externally induced frontoparietal synchronization modulates network dynamics and enhances working memory performance.
Authors: Violante, IR
Li, LM
Carmichael, DW
Lorenz, R
Leech, R
Hampshire, A
Rothwell, JC
Sharp, DJ
Item Type: Journal Article
Abstract: Cognitive functions such as working memory (WM) are emergent properties of large-scale network interactions. Synchronisation of oscillatory activity might contribute to WM by enabling the coordination of long-range processes. However, causal evidence for the way oscillatory activity shapes network dynamics and behavior in humans is limited. Here we applied transcranial alternating current stimulation (tACS) to exogenously modulate oscillatory activity in a right frontoparietal network that supports WM. Externally induced synchronization improved performance when cognitive demands were high. Simultaneously collected fMRI data reveals tACS effects dependent on the relative phase of the stimulation and the internal cognitive processing state. Specifically, synchronous tACS during the verbal WM task increased parietal activity, which correlated with behavioral performance. Furthermore, functional connectivity results indicate that the relative phase of frontoparietal stimulation influences information flow within the WM network. Overall, our findings demonstrate a link between behavioral performance in a demanding WM task and large-scale brain synchronization.
Issue Date: 14-Mar-2017
Date of Acceptance: 6-Feb-2017
URI: http://hdl.handle.net/10044/1/46005
DOI: https://dx.doi.org/10.7554/eLife.22001
ISSN: 2050-084X
Publisher: eLife Sciences Publications
Journal / Book Title: Elife
Volume: 6
Copyright Statement: © 2017, Violante et al. This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use and redistribution provided that the original author and source are credited.
Sponsor/Funder: National Institute for Health Research
Imperial College Healthcare NHS Trust- BRC Funding
Wellcome Trust
Wellcome Trust
Wellcome Trust
Wellcome Trust
Imperial College Healthcare NHS Trust- BRC Funding
Funder's Grant Number: NIHR-RP-011-048
Keywords: Working memory
brain networks
brain stimulation
Publication Status: Published
Conference Place: England
Open Access location: http://dx.doi.org/10.7554/eLife.22001
Article Number: e22001
Appears in Collections:Department of Medicine (up to 2019)