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Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses
| File | Description | Size | Format | |
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 Main Text.pdf | Accepted version | 793.64 kB | Adobe PDF | View/Open |
| Title: | Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses |
| Authors: | Okbay, A Baselmans, BML De Neve, J-E Turley, P Nivard, MG Fontana, MA Meddens, SFW Linner, RK Rietveld, CA Derringer, J Gratten, J Lee, JJ Liu, JZ De Vlaming, R Ahluwalia, TS Buchwald, J Cavadino, A Frazier-Wood, AC Furlotte, NA Garfield, V Geisel, MH Gonzalez, JR Haitjema, S Karlsson, R Van der Laan, SW Ladwig, K-H Lahti, J Van der Lee, SJ Lind, PA Liu, T Matteson, L Mihailov, E Miller, MB Minica, CC Nolte, IM Mook-Kanamori, D Van der Most, PJ Oldmeadow, C Qian, Y Raitakari, O Rawal, R Realo, A Rueedi, R Schmidt, B Smith, AV Stergiakouli, E Tanaka, T Taylor, K Wedenoja, J Wellmann, J Westra, H-J Willems, SM Zhao, W Amin, N Bakshi, A Boyle, PA Cherney, S Cox, SR Davies, G Davis, OSP Ding, J Direk, N Eibich, P Emeny, RT Fatemifar, G Faul, JD Ferrucci, L Forstner, A Gieger, C Gupta, R Harris, TB Harris, JM Holliday, EG Hottenga, J-J De Jager, PL Kaakinen, MA Kajantie, E Karhunen, V Kolcic, I Kumari, M Launer, LJ Franke, L Li-Gao, R Koini, M Loukola, A Marques-Vidal, P Montgomery, GW Mosing, MA Paternoster, L Pattie, A Petrovic, KE Pulkki-Raback, L Quaye, L Raikkonen, K Rudan, I Scott, RJ Smith, JA Sutin, AR Trzaskowski, M Vinkhuyzen, AE Yu, L Zabaneh, D Attia, JR Bennett, DA Berger, K Bertram, L Boomsma, DI Snieder, H Chang, S-C Cucca, F Deary, IJ Van Duijn, CM Eriksson, JG Bultmann, U De Geus, EJC Groenen, PJF Gudnason, V Hansen, T Hartman, CA Haworth, CMA Hayward, C Heath, AC Hinds, DA Hypponen, E Iacono, WG Jarvelin, M-R Jockel, K-H Kaprio, J Kardia, SLR Keltikangas-Jarvinen, L Kraft, P Kubzansky, LD Lehtimaki, T Magnusson, PKE Martin, NG Mcgue, M Metspalu, A Mills, M De Mutsert, R Oldehinkel, AJ Pasterkamp, G Pedersen, NL Plomin, R Polasek, O Power, C Rich, SS Rosendaal, FR Den Ruijter, HM Schlessinger, D Schmidt, H Svento, R Schmidt, R Alizadeh, BZ Sorensen, TIA Spector, TD Steptoe, A Terracciano, A Thurik, AR Timpson, NJ Tiemeier, H Uitterlinden, AG Vollenweider, P Wagner, GG Weir, DR Yang, J Conley, DC Smith, GD Hofman, A Johannesson, M Laibson, DI Medland, SE Meyer, MN Pickrell, JK Esko, T Krueger, RF Beauchamp, JP Koellinger, PD Benjamin, DJ Bartels, M Cesarini, D Thorleifsson, G Bergmann, S Bjornsdottir, G Liewald, DC Starr, JM Stefansson, K Thorsteindottir, U |
| Item Type: | Journal Article |
| Abstract: | Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is genetically correlated with both of these traits, has not yet been studied with genome-wide data. We conducted genome-wide association studies of three phenotypes: subjective well-being (n = 298,420), depressive symptoms (n = 161,460), and neuroticism (n = 170,911). We identify 3 variants associated with subjective well-being, 2 variants associated with depressive symptoms, and 11 variants associated with neuroticism, including 2 inversion polymorphisms. The two loci associated with depressive symptoms replicate in an independent depression sample. Joint analyses that exploit the high genetic correlations between the phenotypes (|ρˆ| ≈ 0.8) strengthen the overall credibility of the findings and allow us to identify additional variants. Across our phenotypes, loci regulating expression in central nervous system and adrenal or pancreas tissues are strongly enriched for association. |
| Issue Date: | 18-Apr-2016 |
| Date of Acceptance: | 24-Mar-2016 |
| URI: | http://hdl.handle.net/10044/1/45805 |
| DOI: | https://dx.doi.org/10.1038/ng.3552 |
| ISSN: | 1061-4036 |
| Publisher: | Nature Publishing Group |
| Start Page: | 624 |
| End Page: | 633 |
| Journal / Book Title: | Nature Genetics |
| Volume: | 48 |
| Issue: | 6 |
| Copyright Statement: | © 2016 Nature America, Inc. All rights reserved |
| Keywords: | Science & Technology Life Sciences & Biomedicine Genetics & Heredity MAJOR DEPRESSION COMMON VARIANTS HUMAN HEIGHT RISK HERITABILITY METAANALYSIS PERSONALITY HAPPINESS RESOURCE DISEASE LifeLines Cohort Study Developmental Biology 11 Medical And Health Sciences 06 Biological Sciences |
| Publication Status: | Published |
| Appears in Collections: | Department of Medicine (up to 2019) |