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Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses

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Title: Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses
Authors: Okbay, A
Baselmans, BML
De Neve, J-E
Turley, P
Nivard, MG
Fontana, MA
Meddens, SFW
Linner, RK
Rietveld, CA
Derringer, J
Gratten, J
Lee, JJ
Liu, JZ
De Vlaming, R
Ahluwalia, TS
Buchwald, J
Cavadino, A
Frazier-Wood, AC
Furlotte, NA
Garfield, V
Geisel, MH
Gonzalez, JR
Haitjema, S
Karlsson, R
Van der Laan, SW
Ladwig, K-H
Lahti, J
Van der Lee, SJ
Lind, PA
Liu, T
Matteson, L
Mihailov, E
Miller, MB
Minica, CC
Nolte, IM
Mook-Kanamori, D
Van der Most, PJ
Oldmeadow, C
Qian, Y
Raitakari, O
Rawal, R
Realo, A
Rueedi, R
Schmidt, B
Smith, AV
Stergiakouli, E
Tanaka, T
Taylor, K
Wedenoja, J
Wellmann, J
Westra, H-J
Willems, SM
Zhao, W
Amin, N
Bakshi, A
Boyle, PA
Cherney, S
Cox, SR
Davies, G
Davis, OSP
Ding, J
Direk, N
Eibich, P
Emeny, RT
Fatemifar, G
Faul, JD
Ferrucci, L
Forstner, A
Gieger, C
Gupta, R
Harris, TB
Harris, JM
Holliday, EG
Hottenga, J-J
De Jager, PL
Kaakinen, MA
Kajantie, E
Karhunen, V
Kolcic, I
Kumari, M
Launer, LJ
Franke, L
Li-Gao, R
Koini, M
Loukola, A
Marques-Vidal, P
Montgomery, GW
Mosing, MA
Paternoster, L
Pattie, A
Petrovic, KE
Pulkki-Raback, L
Quaye, L
Raikkonen, K
Rudan, I
Scott, RJ
Smith, JA
Sutin, AR
Trzaskowski, M
Vinkhuyzen, AE
Yu, L
Zabaneh, D
Attia, JR
Bennett, DA
Berger, K
Bertram, L
Boomsma, DI
Snieder, H
Chang, S-C
Cucca, F
Deary, IJ
Van Duijn, CM
Eriksson, JG
Bultmann, U
De Geus, EJC
Groenen, PJF
Gudnason, V
Hansen, T
Hartman, CA
Haworth, CMA
Hayward, C
Heath, AC
Hinds, DA
Hypponen, E
Iacono, WG
Jarvelin, M-R
Jockel, K-H
Kaprio, J
Kardia, SLR
Keltikangas-Jarvinen, L
Kraft, P
Kubzansky, LD
Lehtimaki, T
Magnusson, PKE
Martin, NG
Mcgue, M
Metspalu, A
Mills, M
De Mutsert, R
Oldehinkel, AJ
Pasterkamp, G
Pedersen, NL
Plomin, R
Polasek, O
Power, C
Rich, SS
Rosendaal, FR
Den Ruijter, HM
Schlessinger, D
Schmidt, H
Svento, R
Schmidt, R
Alizadeh, BZ
Sorensen, TIA
Spector, TD
Steptoe, A
Terracciano, A
Thurik, AR
Timpson, NJ
Tiemeier, H
Uitterlinden, AG
Vollenweider, P
Wagner, GG
Weir, DR
Yang, J
Conley, DC
Smith, GD
Hofman, A
Johannesson, M
Laibson, DI
Medland, SE
Meyer, MN
Pickrell, JK
Esko, T
Krueger, RF
Beauchamp, JP
Koellinger, PD
Benjamin, DJ
Bartels, M
Cesarini, D
Thorleifsson, G
Bergmann, S
Bjornsdottir, G
Liewald, DC
Starr, JM
Stefansson, K
Thorsteindottir, U
Item Type: Journal Article
Abstract: Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is genetically correlated with both of these traits, has not yet been studied with genome-wide data. We conducted genome-wide association studies of three phenotypes: subjective well-being (n = 298,420), depressive symptoms (n = 161,460), and neuroticism (n = 170,911). We identify 3 variants associated with subjective well-being, 2 variants associated with depressive symptoms, and 11 variants associated with neuroticism, including 2 inversion polymorphisms. The two loci associated with depressive symptoms replicate in an independent depression sample. Joint analyses that exploit the high genetic correlations between the phenotypes (|ρˆ| ≈ 0.8) strengthen the overall credibility of the findings and allow us to identify additional variants. Across our phenotypes, loci regulating expression in central nervous system and adrenal or pancreas tissues are strongly enriched for association.
Issue Date: 18-Apr-2016
Date of Acceptance: 24-Mar-2016
URI: http://hdl.handle.net/10044/1/45805
DOI: https://dx.doi.org/10.1038/ng.3552
ISSN: 1061-4036
Publisher: Nature Publishing Group
Start Page: 624
End Page: 633
Journal / Book Title: Nature Genetics
Volume: 48
Issue: 6
Copyright Statement: © 2016 Nature America, Inc. All rights reserved
Keywords: Science & Technology
Life Sciences & Biomedicine
Genetics & Heredity
MAJOR DEPRESSION
COMMON VARIANTS
HUMAN HEIGHT
RISK
HERITABILITY
METAANALYSIS
PERSONALITY
HAPPINESS
RESOURCE
DISEASE
LifeLines Cohort Study
Developmental Biology
11 Medical And Health Sciences
06 Biological Sciences
Publication Status: Published
Appears in Collections:Department of Medicine (up to 2019)