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Addressing unmet needs in understanding asthma mechanisms

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Title: Addressing unmet needs in understanding asthma mechanisms
Authors: Edwards, MR
Saglani, S
Schwarze, J
Skevaki, C
Smith, JA
Ainsworth, B
Almond, M
Andreakos, E
Belvisi, MG
Chung, KF
Cookson, W
Cullinan, P
Hawrylowicz, C
Lommatzsch, M
Jackson, DJ
Lutter, R
Marsland, B
Moffatt, M
Thomas, M
Virchow, JC
Xanthou, G
Edwards, J
Walker, S
Johnston, SL
Item Type: Journal Article
Abstract: Asthma is a heterogeneous, complex disease with clinical phenotypes that incorporate persistent symptoms and acute exacerbations. It affects many millions of Europeans throughout their education and working lives and puts a heavy cost on European productivity. There is a wide spectrum of disease severity and control. Therapeutic advances have been slow despite greater understanding of basic mechanisms and the lack of satisfactory preventative and disease modifying management for asthma constitutes a significant unmet clinical need. Preventing, treating and ultimately curing asthma requires co-ordinated research and innovation across Europe. The European Asthma Research and Innovation Partnership (EARIP) is an FP7-funded programme which has taken a co-ordinated and integrated approach to analyse the future of asthma research and development. This report aims to identify the mechanistic areas in which investment is required to bring about significant improvements in asthma outcomes.
Issue Date: 1-May-2017
Date of Acceptance: 13-Mar-2017
URI: http://hdl.handle.net/10044/1/45616
DOI: https://dx.doi.org/10.1183/13993003.02448-2016
ISSN: 1399-3003
Publisher: European Respiratory Society: ERJ
Journal / Book Title: European Respiratory Journal
Volume: 49
Issue: 5
Copyright Statement: © ERS 2017
Sponsor/Funder: Medical Research Council (MRC)
Commission of the European Communities
Commission of the European Communities
GlaxoSmithKline Services Unlimited
Asthma UK
Funder's Grant Number: G1100238
Asthma UK Centre
Keywords: Respiratory System
11 Medical And Health Sciences
Publication Status: Published
Article Number: 1602448
Appears in Collections:National Heart and Lung Institute