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Predicting surgical outcome in patients with glioblastoma multiforme using pre-operative magnetic resonance imaging: development and preliminary validation of a grading system.

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Title: Predicting surgical outcome in patients with glioblastoma multiforme using pre-operative magnetic resonance imaging: development and preliminary validation of a grading system.
Authors: Marcus, HJ
Williams, S
Hughes-Hallett, A
Camp, SJ
Nandi, D
Thorne, L
Item Type: Journal Article
Abstract: The lack of a simple, objective and reproducible system to describe glioblastoma multiforme (GBM) represents a major limitation in comparative effectiveness research. The objectives of this study were therefore to develop such a grading system and to validate it on patients who underwent surgical resection. A systematic review of the literature was performed to identify features on pre-operative magnetic resonance imaging (MRI) that predict the surgical outcome of patients with GBM. In all, the five most important features of GBM on pre-operative MRI were as follows: periventricular or deep location, corpus callosum or bilateral location, eloquent location, size and associated oedema. These were then used to develop a grading system. To validate this grading system, a retrospective cohort study of all adult patients with supratentorial GBM who underwent surgical resection between the 1 January 2014 and the 31 June 2015 was performed. There was a substantial agreement between the two neurosurgeons grading GBM (Cohen's κ was 0.625; standard error 0.066). High-complexity lesions were significantly less likely to result in complete resection of contrast-enhancing tumour than low-complexity lesions (50.0 versus 3.4%; p = 0.0007). The proposed grading system may allow for the standardised communication of anatomical features of GBM identified on pre-operative MRI.
Issue Date: 15-Feb-2017
Date of Acceptance: 18-Jan-2017
URI: http://hdl.handle.net/10044/1/45615
DOI: https://dx.doi.org/10.1007/s10143-017-0817-0
ISSN: 1437-2320
Publisher: Springer Verlag
Start Page: 621
End Page: 631
Journal / Book Title: Neurosurgical Review
Volume: 40
Issue: 4
Copyright Statement: © 2017 The Author(s). Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Keywords: Complications
Glioblastoma multiforme
Magnetic resonance imaging
Resection
Surgical outcome
1103 Clinical Sciences
1109 Neurosciences
Neurology & Neurosurgery
Publication Status: Published
Open Access location: http://link.springer.com/article/10.1007/s10143-017-0817-0
Appears in Collections:Department of Medicine (up to 2019)