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Exploring the significance of morphological diversity for cerebellar granule cell excitability

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Title: Exploring the significance of morphological diversity for cerebellar granule cell excitability
Authors: Houston, C
Diamanti, E
Diamantaki, M
Kutsarova, E
Cook, A
Sultan, F
Brickley, SG
Item Type: Journal Article
Abstract: The relatively simple and compact morphology of cerebellar granule cells (CGCs) has led to the view that heterogeneity in CGC shape has negligible impact upon the integration of mossy fibre (MF) information. Following electrophysiological recording, 3D models were constructed from high-resolution imaging data to identify morphological features that could influence the coding of MF input patterns by adult CGCs. Quantification of MF and CGC morphology provided evidence that CGCs could be connected to the multiple rosettes that arise from a single MF input. Predictions from our computational models propose that MF inputs could be more densely encoded within the CGC layer than previous models suggest. Moreover, those MF signals arriving onto the dendrite closest to the axon will generate greater CGC excitation. However, the impact of this morphological variability on MF input selectivity will be attenuated by high levels of CGC inhibition providing further flexibility to the MF → CGC pathway. These features could be particularly important when considering the integration of multimodal MF sensory input by individual CGCs.
Issue Date: 13-Apr-2017
Date of Acceptance: 13-Mar-2017
URI: http://hdl.handle.net/10044/1/45601
DOI: https://dx.doi.org/10.1038/srep46147
ISSN: 2045-2322
Publisher: Nature Publishing Group
Journal / Book Title: Scientific Reports
Volume: 7
Copyright Statement: © The Author(s) 2017. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Keywords: Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
LONG-TERM POTENTIATION
MOSSY FIBER
SYNAPTIC INTEGRATION
SENSORY INFORMATION
GABA(A) RECEPTORS
SUBSTANTIA-NIGRA
RAT CEREBELLUM
IN-VIVO
NEURONS
CORTEX
Publication Status: Published
Article Number: 46147
Appears in Collections:Faculty of Natural Sciences