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Signatures of malaria-associated pathology revealed by high-resolution whole-blood transcriptomics in a rodent model of malaria.

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Lin J_---O'Garra, Langhorne Maralia signature mouse Scientific Reports 2017.pdfPublished version2.24 MBAdobe PDFView/Open
Title: Signatures of malaria-associated pathology revealed by high-resolution whole-blood transcriptomics in a rodent model of malaria.
Authors: Lin, JW
Sodenkamp, J
Cunningham, D
Deroost, K
Tshitenge, TC
McLaughlin, S
Lamb, TJ
Spencer-Dene, B
Hosking, C
Ramesar, J
Janse, CJ
Graham, C
O'Garra, A
Langhorne, J
Item Type: Journal Article
Abstract: The influence of parasite genetic factors on immune responses and development of severe pathology of malaria is largely unknown. In this study, we performed genome-wide transcriptomic profiling of mouse whole blood during blood-stage infections of two strains of the rodent malaria parasite Plasmodium chabaudi that differ in virulence. We identified several transcriptomic signatures associated with the virulent infection, including signatures for platelet aggregation, stronger and prolonged anemia and lung inflammation. The first two signatures were detected prior to pathology. The anemia signature indicated deregulation of host erythropoiesis, and the lung inflammation signature was linked to increased neutrophil infiltration, more cell death and greater parasite sequestration in the lungs. This comparative whole-blood transcriptomics profiling of virulent and avirulent malaria shows the validity of this approach to inform severity of the infection and provide insight into pathogenic mechanisms.
Issue Date: 3-Feb-2017
Date of Acceptance: 28-Dec-2016
URI: http://hdl.handle.net/10044/1/45461
DOI: https://dx.doi.org/10.1038/srep41722
ISSN: 2045-2322
Publisher: Nature Publishing Group
Journal / Book Title: Scientific Reports
Volume: 7
Copyright Statement: © 2017 The Author(s). This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Publication Status: Published
Conference Place: England
Article Number: 41722
Appears in Collections:National Heart and Lung Institute