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In vivo endoscopic tissue identification tool utilising Rapid Evaporative Ionization Mass Spectrometry (REIMS)

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Title: In vivo endoscopic tissue identification tool utilising Rapid Evaporative Ionization Mass Spectrometry (REIMS)
Authors: Balog, J
Kumar
Alexander, J
Golf, O
Huang, J
Abbassi-Ghadi
Wiggins, T
Abbassi-Ghadi, N
Enyedi, A
Kacska, S
Kinross, J
Hanna, G
Nicholson, JK
Takats, Z
Item Type: Journal Article
Abstract: Gastrointestinal cancers are a leading cause of mortality, accounting for 23 % of cancer-related deaths worldwide. In order to improve outcomes from these cancers, novel tissue characterization methods are needed to facilitate accurate diagnosis. Rapid evaporative ionization mass spectrometry (REIMS) is a technique developed for the in vivo classification of human tissue through mass spectrometric analysis of aerosols released during electrosurgical dissection. This ionization technique was further developed by utilizing surface induced dissociation and was integrated with an endoscopic polypectomy snare to allow in vivo analysis of the gastrointestinal tract. We tested the classification performance of this novel endoscopic REIMS method in vivo. It was shown to be capable of differentiating between healthy layers of the intestinal wall, cancer, and adenomatous polyps based on the REIMS fingerprint of each tissue type in vivo.
Issue Date: 6-Aug-2015
Date of Acceptance: 8-Jul-2015
URI: http://hdl.handle.net/10044/1/45401
DOI: https://dx.doi.org/10.1002/anie.201502770
ISSN: 1433-7851
Publisher: Wiley
Start Page: 11059
End Page: 11062
Journal / Book Title: Angewandte Chemie International Edition
Volume: 54
Issue: 38
Copyright Statement: © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the accepted version of the following article: Balog, J., Kumar, S., Alexander, J., Golf, O., Huang, J., Wiggins, T., Abbassi-Ghadi, N., Enyedi, A., Kacska, S., Kinross, J., Hanna, G. B., Nicholson, J. K. and Takats, Z. (2015), In Vivo Endoscopic Tissue Identification by Rapid Evaporative Ionization Mass Spectrometry (REIMS). Angew. Chem. Int. Ed., 54: 11059–11062. doi:10.1002/anie.201502770, which has been published in final form at https://dx.doi.org/10.1002/anie.201502770
Sponsor/Funder: Imperial College Healthcare NHS Trust- BRC Funding
Imperial College Healthcare NHS Trust- BRC Funding
Imperial College Healthcare NHS Trust- BRC Funding
Commission of the European Communities
Funder's Grant Number: RDB03 79560
RDB04 79560
RD207
617896
Keywords: Science & Technology
Physical Sciences
Chemistry, Multidisciplinary
Chemistry
cancer
endoscopy
in vivo characterization
mass spectrometry
phospholipids
OPTICAL COHERENCE TOMOGRAPHY
CANCER
COLONOSCOPY
RESECTION
PROBE
in vivo characterization
Endoscopy, Gastrointestinal
Gastrointestinal Neoplasms
Humans
Mass Spectrometry
Organic Chemistry
03 Chemical Sciences
Publication Status: Published
Appears in Collections:Department of Surgery and Cancer