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T cell immunoengineering with advanced biomaterials

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Delcassian T cell Immunoengineering.pdfAccepted version1.26 MBAdobe PDFView/Open
c6ib00233a.pdfPublished version3.84 MBAdobe PDFView/Open
Title: T cell immunoengineering with advanced biomaterials
Authors: Delcassian, D
Sattler, S
Dunlop, IE
Item Type: Journal Article
Abstract: Recent advances in biomaterials design offer the potential to actively control immune cell activation and behaviour. Many human diseases, such as infections, cancer, and autoimmune disorders, are partly mediated by inappropriate or insufficient activation of the immune system. T cells play a central role in the host immune response to these diseases, and so constitute a promising cell type for manipulation. In vivo, T cells are stimulated by antigen presenting cells (APC), therefore to design immunoengineering biomaterials that control T cell behaviour, artificial interfaces that mimic the natural APC-T cell interaction are required. This review draws together research in the design and fabrication of such biomaterial interfaces, and highlights efforts to elucidate key parameters in T cell activation, such as substrate mechanical properties and spatial organization of receptors, illustrating how they can be manipulated by bioengineering approaches to alter T cell function.
Issue Date: 20-Feb-2017
Date of Acceptance: 15-Feb-2017
URI: http://hdl.handle.net/10044/1/44711
DOI: https://dx.doi.org/10.1039/C6IB00233A
ISSN: 1757-9694
Publisher: Royal Society of Chemistry
Start Page: 211
End Page: 222
Journal / Book Title: Integrative Biology
Volume: 9
Copyright Statement: This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Sponsor/Funder: British Heart Foundation
Funder's Grant Number: RM/13/1/30157
Keywords: Science & Technology
Life Sciences & Biomedicine
Cell Biology
ANTIGEN-PRESENTING CELLS
IMMUNOLOGICAL SYNAPSE STRUCTURE
CLASS-II MOLECULES
ACTIN CYTOSKELETON
L-SELECTIN
SYNTHETIC NANOPARTICLES
ADOPTIVE IMMUNOTHERAPY
RECEPTOR MICROCLUSTERS
LYMPHOCYTE-ACTIVATION
SUBSTRATE ELASTICITY
General Science & Technology
Publication Status: Published
Appears in Collections:Materials
National Heart and Lung Institute
Faculty of Natural Sciences
Faculty of Engineering