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Exploiting receptor competition to enhance nanoparticle binding selectivity

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Title: Exploiting receptor competition to enhance nanoparticle binding selectivity
Authors: Angioletti-Uberti, S
Item Type: Journal Article
Abstract: Nanoparticles functionalized with multiple ligands can be programmed to bind biological targets depending on the receptors they express, providing a general mechanism exploited in various technologies, from selective drug-delivery to biosensing. For binding to be highly selective, ligands should exclusively interact with specific targeted receptors, because formation of bonds with other, untargeted ones would lead to non-specific binding and potentially harmful behaviour. This poses a particular problem for multivalent nanoparticles, because even very weak bonds can collectively lead to strong binding. A statistical mechanical model is used here to describe how competition between different receptors together with multivalent effects can be harnessed to design ligand-functionalized nanoparticles insensitive to the presence of untargeted receptors, preventing non-specific binding.
Issue Date: 10-Feb-2017
Date of Acceptance: 18-Jan-2017
URI: http://hdl.handle.net/10044/1/44143
DOI: 10.1103/PhysRevLett.118.068001
ISSN: 0031-9007
Publisher: American Physical Society
Start Page: 1
End Page: 5
Journal / Book Title: Physical Review Letters
Volume: 118
Issue: 6
Copyright Statement: © 2017 American Physical Society
Keywords: Nanoparticles, Drug-delivery, Statistical Mechanics, Multivalency
Science & Technology
Physical Sciences
Physics, Multidisciplinary
Physics
DNA-COATED COLLOIDS
LOW-AFFINITY
MULTIVALENT
DESIGN
physics.chem-ph
physics.chem-ph
cond-mat.soft
cond-mat.stat-mech
01 Mathematical Sciences
02 Physical Sciences
09 Engineering
General Physics
Publication Status: Published
Article Number: 068001
Online Publication Date: 2017-02-08
Appears in Collections:Materials
Faculty of Engineering