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Exploiting receptor competition to enhance nanoparticle binding selectivity
File | Description | Size | Format | |
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PhysRevLett.118.068001.pdf | Published version | 510.7 kB | Adobe PDF | View/Open |
Title: | Exploiting receptor competition to enhance nanoparticle binding selectivity |
Authors: | Angioletti-Uberti, S |
Item Type: | Journal Article |
Abstract: | Nanoparticles functionalized with multiple ligands can be programmed to bind biological targets depending on the receptors they express, providing a general mechanism exploited in various technologies, from selective drug-delivery to biosensing. For binding to be highly selective, ligands should exclusively interact with specific targeted receptors, because formation of bonds with other, untargeted ones would lead to non-specific binding and potentially harmful behaviour. This poses a particular problem for multivalent nanoparticles, because even very weak bonds can collectively lead to strong binding. A statistical mechanical model is used here to describe how competition between different receptors together with multivalent effects can be harnessed to design ligand-functionalized nanoparticles insensitive to the presence of untargeted receptors, preventing non-specific binding. |
Issue Date: | 10-Feb-2017 |
Date of Acceptance: | 18-Jan-2017 |
URI: | http://hdl.handle.net/10044/1/44143 |
DOI: | 10.1103/PhysRevLett.118.068001 |
ISSN: | 0031-9007 |
Publisher: | American Physical Society |
Start Page: | 1 |
End Page: | 5 |
Journal / Book Title: | Physical Review Letters |
Volume: | 118 |
Issue: | 6 |
Copyright Statement: | © 2017 American Physical Society |
Keywords: | Nanoparticles, Drug-delivery, Statistical Mechanics, Multivalency Science & Technology Physical Sciences Physics, Multidisciplinary Physics DNA-COATED COLLOIDS LOW-AFFINITY MULTIVALENT DESIGN physics.chem-ph physics.chem-ph cond-mat.soft cond-mat.stat-mech 01 Mathematical Sciences 02 Physical Sciences 09 Engineering General Physics |
Publication Status: | Published |
Article Number: | 068001 |
Online Publication Date: | 2017-02-08 |
Appears in Collections: | Materials Faculty of Engineering |