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Hepatic steatosis and fibrosis: Non-invasive assessment

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Title: Hepatic steatosis and fibrosis: Non-invasive assessment
Authors: Karanjia, RN
Crossey, MME
Cox, IJ
Fye, HKS
Njie, R
Goldin, RD
Taylor-Robinson, SD
Item Type: Journal Article
Abstract: Chronic liver disease is a major cause of morbidity and mortality worldwide and usually develops over many years, as a result of chronic inflammation and scarring, resulting in end-stage liver disease and its complications. The progression of disease is characterised by ongoing inflammation and consequent fibrosis, although hepatic steatosis is increasingly being recognised as an important pathological feature of disease, rather than being simply an innocent bystander. However, the current gold standard method of quantifying and staging liver disease, histological analysis by liver biopsy, has several limitations and can have associated morbidity and even mortality. Therefore, there is a clear need for safe and noninvasive assessment modalities to determine hepatic steatosis, inflammation and fibrosis. This review covers key mechanisms and the importance of fibrosis and steatosis in the progression of liver disease. We address non-invasive imaging and blood biomarker assessments that can be used as an alternative to information gained on liver biopsy.
Issue Date: 7-Dec-2016
Date of Acceptance: 15-Nov-2016
URI: http://hdl.handle.net/10044/1/43356
DOI: https://dx.doi.org/10.3748/wjg.v22.i45.9880
ISSN: 1007-9327
Publisher: Baishideng Publishing Group Inc.
Start Page: 9880
End Page: 9897
Journal / Book Title: World Journal of Gastroenterology
Volume: 22
Issue: 45
Copyright Statement: ┬ęThe Author(s) 2016. Published by Baishideng Publishing Group Inc. This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Sponsor/Funder: Medical Research Council (MRC)
Wellcome Trust
Institut Merieux
Funder's Grant Number: MC_PC_12015
105603/Z/14/Z
N/A
Keywords: Gastroenterology & Hepatology
1103 Clinical Sciences
Publication Status: Published
Appears in Collections:Department of Surgery and Cancer