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Alcohol consumption and the risk of renal cancers in the European prospective investigation into cancer and nutrition (EPIC)

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Title: Alcohol consumption and the risk of renal cancers in the European prospective investigation into cancer and nutrition (EPIC)
Authors: Wozniak, MB
Brennan, P
Brenner, DR
Overvad, K
Olsen, A
Tjonneland, A
Boutron-Ruault, M-C
Clavel-Chapelon, F
Fagherazzi, G
Katzke, V
Kuehn, T
Boeing, H
Bergmann, MM
Steffen, A
Naska, A
Trichopoulou, A
Trichopoulos, D
Saieva, C
Grioni, S
Panico, S
Tumino, R
Vineis, P
Bueno-de-Mesquita, HBA
Peeters, PH
Hjartaker, A
Weiderpass, E
Arriola, L
Molina-Montes, E
Duell, EJ
Santiuste, C
Alonso de la Torre, R
Barricarte Gurrea, A
Stocks, T
Johansson, M
Ljungberg, B
Wareham, N
Khaw, K-T
Travis, RC
Cross, AJ
Murphy, N
Riboli, E
Scelo, G
Item Type: Journal Article
Abstract: Epidemiologic studies have reported that moderate alcohol consumption is inversely associated with the risk of renal cancer. However, there is no information available on the associations in renal cancer subsites. From 1992 through to 2010, 477,325 men and women in the European Prospective Investigation into Cancer and Nutrition cohort were followed for incident renal cancers (n = 931). Baseline and lifetime alcohol consumption was assessed by country-specific, validated dietary questionnaires. Information on past alcohol consumption was collected by lifestyle questionnaires. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated from Cox proportional hazard models. In multivariate analysis, total alcohol consumption at baseline was inversely associated with renal cancer; the HR and 95% CI for the increasing categories of total alcohol consumption at recruitment versus the light drinkers category were 0.78 (0.62–0.99), 0.82 (0.64–1.04), 0.70 (0.55–0.90), 0.91 (0.63–1.30), respectively, (ptrend = 0.001). A similar relationship was observed for average lifetime alcohol consumption and for all renal cancer subsites combined or for renal parenchyma subsite. The trend was not observed in hypertensive individuals and not significant in smokers. In conclusion, moderate alcohol consumption was associated with a decreased risk of renal cancer.
Issue Date: 9-Apr-2015
Date of Acceptance: 16-Mar-2015
URI: http://hdl.handle.net/10044/1/42687
DOI: http://dx.doi.org/10.1002/ijc.29559
ISSN: 1097-0215
Publisher: Wiley
Start Page: 1953
End Page: 1966
Journal / Book Title: International Journal of Cancer
Volume: 137
Issue: 8
Copyright Statement: © 2015 UICC.
Sponsor/Funder: Imperial College Trust
Funder's Grant Number: P47328
Keywords: Science & Technology
Life Sciences & Biomedicine
Oncology
kidney cancer
renal cell carcinoma
risk factors
alcohol consumption
EPIC
cohort study
CELL CARCINOMA
KIDNEY CANCER
FLUID INTAKE
WOMEN
METAANALYSIS
COUNTRIES
DRINKING
COHORT
DIET
EPIDEMIOLOGY
Alcohol Drinking
Europe
Female
Humans
Kidney Neoplasms
Life Style
Male
Proportional Hazards Models
Prospective Studies
Risk Factors
Surveys and Questionnaires
Oncology & Carcinogenesis
1112 Oncology And Carcinogenesis
Publication Status: Published
Appears in Collections:School of Public Health



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