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Characterization of progressive HIV-associated tuberculosis using 2-deoxy-2-[(18)F]fluoro-D-glucose positron emission and computed tomography

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Title: Characterization of progressive HIV-associated tuberculosis using 2-deoxy-2-[(18)F]fluoro-D-glucose positron emission and computed tomography
Authors: Esmail, H
Lai, RP
Lesosky, M
Wilkinson, KA
Graham, CM
Coussens, AK
Oni, T
Warwick, JM
Said-Hartley, Q
Koegelenberg, CF
Walzl, G
Flynn, JL
Young, DB
Barry Iii, CE
O'Garra, A
Wilkinson, RJ
Item Type: Journal Article
Abstract: Tuberculosis is classically divided into states of latent infection and active disease. Using combined positron emission and computed tomography in 35 asymptomatic, antiretroviral-therapy-naive, HIV-1-infected adults with latent tuberculosis, we identified ten individuals with pulmonary abnormalities suggestive of subclinical, active disease who were substantially more likely to progress to clinical disease. Our findings challenge the conventional two-state paradigm and may aid future identification of biomarkers that are predictive of progression.
Issue Date: 5-Sep-2016
Date of Acceptance: 8-Jul-2016
URI: http://hdl.handle.net/10044/1/42188
DOI: 10.1038/nm.4161
ISSN: 1546-170X
Publisher: Nature Publishing Group
Start Page: 1090
End Page: 1093
Journal / Book Title: Nature Medicine
Volume: 22
Copyright Statement: © 2016 Nature America, Inc. All rights reserved.
Sponsor/Funder: Wellcome Trust
Wellcome Trust
Funder's Grant Number: 090170/Z/09/Z
104803/Z/14/Z
Keywords: Science & Technology
Life Sciences & Biomedicine
Biochemistry & Molecular Biology
Cell Biology
Medicine, Research & Experimental
Research & Experimental Medicine
PULMONARY TUBERCULOSIS
ACTIVE TUBERCULOSIS
FUTURE-PROSPECTS
INFECTION
PREVALENCE
STRATEGIES
DISEASE
ADULTS
LUNG
Adult
Coinfection
Disease Progression
Female
Fluorodeoxyglucose F18
HIV Infections
Humans
Interferon-gamma Release Tests
Latent Tuberculosis
Male
Mycobacterium tuberculosis
Positron Emission Tomography Computed Tomography
Radiography, Thoracic
Radiopharmaceuticals
South Africa
Sputum
Tuberculosis
Tuberculosis, Pulmonary
Sputum
Humans
Mycobacterium tuberculosis
Tuberculosis
Tuberculosis, Pulmonary
HIV Infections
Disease Progression
Fluorodeoxyglucose F18
Radiopharmaceuticals
Radiography, Thoracic
Adult
South Africa
Female
Male
Latent Tuberculosis
Coinfection
Interferon-gamma Release Tests
Positron Emission Tomography Computed Tomography
Immunology
11 Medical and Health Sciences
Publication Status: Published
Online Publication Date: 2016-09-05
Appears in Collections:Department of Infectious Diseases
National Heart and Lung Institute
Faculty of Medicine