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Roux-en-Y Gastric Bypass and Vertical Banded Gastroplasty Induce Long-Term Changes on the Human Gut Microbiome Contributing to Fat Mass Regulation

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Title: Roux-en-Y Gastric Bypass and Vertical Banded Gastroplasty Induce Long-Term Changes on the Human Gut Microbiome Contributing to Fat Mass Regulation
Authors: Tremaroli, V
Karlsson, F
Werling, M
Ståhlman, M
Kovatcheva-Datchary, P
Olbers, T
Fändriks, L
Le Roux, CW
Nielsen, J
Bäckhed, F
Item Type: Journal Article
Abstract: Bariatric surgery is currently the most effective procedure for the treatment of obesity. Given the role of the gut microbiota in regulating host metabolism and adiposity, we investigated the long-term effects of bariatric surgery on the microbiome of patients randomized to Roux-en-Y gastric bypass or vertical banded gastroplasty and matched for weight and fat mass loss. The two surgical procedures induced similar and durable changes on the gut microbiome that were not dependent on body mass index and resulted in altered levels of fecal and circulating metabolites compared with obese controls. By colonizing germ-free mice with stools from the patients, we demonstrated that the surgically altered microbiota promoted reduced fat deposition in recipient mice. These mice also had a lower respiratory quotient, indicating decreased utilization of carbohydrates as fuel. Our results suggest that the gut microbiota may play a direct role in the reduction of adiposity observed after bariatric surgery.
Issue Date: 4-Aug-2015
Date of Acceptance: 1-Jul-2015
URI: http://hdl.handle.net/10044/1/41941
DOI: http://dx.doi.org/10.1016/j.cmet.2015.07.009
ISSN: 1932-7420
Publisher: Elsevier
Start Page: 228
End Page: 238
Journal / Book Title: Cell Metabolism
Volume: 22
Issue: 2
Copyright Statement: This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Sponsor/Funder: ONO Pharmaceuticals Co Ltd
Funder's Grant Number: N/A
Keywords: Adiposity
Animals
Body Mass Index
Female
Follow-Up Studies
Gastric Bypass
Humans
Intestines
Mice
Microbiota
Obesity
Endocrinology & Metabolism
0601 Biochemistry And Cell Biology
1101 Medical Biochemistry And Metabolomics
Publication Status: Published
Appears in Collections:Department of Medicine (up to 2019)