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S6K2: The Neglected S6 Kinase Family Member.

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Title: S6K2: The Neglected S6 Kinase Family Member.
Authors: Pardo, OE
Seckl, MJ
Item Type: Journal Article
Abstract: S6 kinase 2 (S6K2) is a member of the AGC kinases super-family. Its closest homolog, S6K1, has been extensively studied along the years. However, due to the belief in the community that the high degree of identity between these two isoforms would translate in essentially identical biological functions, S6K2 has been largely neglected. Nevertheless, recent research has clearly highlighted that these two proteins significantly differ in their roles in vitro as well as in vivo. These findings are significant to our understanding of S6 kinase signaling and the development of therapeutic strategies for several diseases including cancer. Here, we will focus on S6K2 and review the protein-protein interactions and specific substrates that determine the selective functions of this kinase.
Issue Date: 24-Jul-2013
Date of Acceptance: 8-Jul-2013
URI: http://hdl.handle.net/10044/1/41888
DOI: https://dx.doi.org/10.3389/fonc.2013.00191
ISSN: 2234-943X
Publisher: Frontiers Media
Journal / Book Title: Frontiers in Oncology
Volume: 3
Copyright Statement: Copyright © 2013 Pardo and Seckl. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
Keywords: RPS6KB2
S6 kinase
S6K2
cancer
function
selectivity
specificity
Publication Status: Published
Article Number: 191
Appears in Collections:Department of Surgery and Cancer