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Whole genome association studies in complex diseases: where do we stand?

Title: Whole genome association studies in complex diseases: where do we stand?
Authors: Need, AC
Goldstein, DB
Item Type: Journal Article
Abstract: Hundreds of genome-wide association studies have been performed in recent years in order to try to identify common variants that associate with complex disease. These have met with varying success. Some of the strongest effects of common variants have been found in late-onset diseases and in drug response. The major histocompatibility complex has also shown very strong association with a variety of disorders. Although there have been some notable success stories in neuropsychiatric genetics, on the whole, common variation has explained little of the high heritability of these traits. In contrast, early studies of rare copy number variants have led rapidly to a number of genes and loci that strongly associate with neuropsychiatric disorders. It is likely that the use of whole-genome sequencing to extend the study of rare variation in neuropsychiatry will greatly advance our understanding of neuropsychiatric genetics.
Issue Date: 31-Mar-2010
Date of Acceptance: 1-Mar-2010
URI: http://hdl.handle.net/10044/1/41675
ISSN: 1958-5969
Publisher: Les Laboratories Servier
Start Page: 37
End Page: 46
Journal / Book Title: Dialogues in Clinical Neuroscience
Volume: 12
Issue: 1
Keywords: Chromosome Mapping
Genetic Predisposition to Disease
Genetic Variation
Genome-Wide Association Study
Humans
Mental Disorders
Models, Genetic
Pharmacogenetics
Psychiatry
Publication Status: Published
Open Access location: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181943/
Appears in Collections:Department of Medicine (up to 2019)



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