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Population Genomics of Cardiometabolic Traits: Design of the University College London-London School of Hygiene and Tropical Medicine-Edinburgh-Bristol (UCLEB) Consortium

Title: Population Genomics of Cardiometabolic Traits: Design of the University College London-London School of Hygiene and Tropical Medicine-Edinburgh-Bristol (UCLEB) Consortium
Authors: Shah, T
Engmann, J
Dale, C
Shah, S
White, J
Giambartolomei, C
McLachlan, S
Zabaneh, D
Cavadino, A
Finan, C
Wong, A
Amuzu, A
Ong, K
Gaunt, T
Holmes, MV
Warren, H
Swerdlow, DI
Davies, TL
Drenos, F
Cooper, J
Sofat, R
Caulfield, M
Ebrahim, S
Lawlor, DA
Talmud, PJ
Humphries, SE
Power, C
Hypponen, E
Richards, M
Hardy, R
Kuh, D
Wareham, N
Langenberg, C
Ben-Shlomo, Y
Day, IN
Whincup, P
Morris, R
Strachan, MW
Price, J
Kumari, M
Kivimaki, M
Plagnol, V
Dudbridge, F
Whittaker, JC
Casas, JP
Hingorani, AD
Item Type: Journal Article
Abstract: Substantial advances have been made in identifying common genetic variants influencing cardiometabolic traits and disease outcomes through genome wide association studies. Nevertheless, gaps in knowledge remain and new questions have arisen regarding the population relevance, mechanisms, and applications for healthcare. Using a new high-resolution custom single nucleotide polymorphism (SNP) array (Metabochip) incorporating dense coverage of genomic regions linked to cardiometabolic disease, the University College-London School-Edinburgh-Bristol (UCLEB) consortium of highly-phenotyped population-based prospective studies, aims to: (1) fine map functionally relevant SNPs; (2) precisely estimate individual absolute and population attributable risks based on individual SNPs and their combination; (3) investigate mechanisms leading to altered risk factor profiles and CVD events; and (4) use Mendelian randomisation to undertake studies of the causal role in CVD of a range of cardiovascular biomarkers to inform public health policy and help develop new preventative therapies.
Issue Date: 20-Aug-2013
Date of Acceptance: 29-Jun-2013
URI: http://hdl.handle.net/10044/1/40054
DOI: http://dx.doi.org/10.1371/journal.pone.0071345
ISSN: 1932-6203
Publisher: Public Library of Science
Journal / Book Title: PLOS One
Volume: 8
Issue: 8
Copyright Statement: © 2013 Shah et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Keywords: Adult
Aged
Aged, 80 and over
Cardiovascular Diseases
Female
Genetic Association Studies
Genetic Markers
Genome, Human
Genome-Wide Association Study
Humans
Longitudinal Studies
Male
Metabolic Networks and Pathways
Metagenomics
Middle Aged
Oligonucleotide Array Sequence Analysis
Polymorphism, Single Nucleotide
Research Design
Risk Factors
UCLEB Consortium
General Science & Technology
MD Multidisciplinary
Publication Status: Published
Article Number: e71345
Appears in Collections:Department of Medicine (up to 2019)