IRUS Total

Integrating inflammasome signaling in sexually transmitted infections

File Description SizeFormat 
Anand-Final TI Accepted Manuscript.pdfAccepted version1.61 MBAdobe PDFView/Open
1-s2.0-S1471490616300941-main.pdfPublished version2.35 MBAdobe PDFView/Open
Title: Integrating inflammasome signaling in sexually transmitted infections
Authors: Lupfer, C
Anand, PK
Item Type: Journal Article
Abstract: Inflammasomes are cytosolic multiprotein platforms with pivotal roles in infectious diseases. Activation of inflammasomes results in pro-inflammatory cytokine signaling and pyroptosis. Sexually transmitted infections are a major health problem worldwide, yet few studies have probed the impact of inflammasome signaling during these infections. Due to the dearth of appropriate infection models, our current understanding of inflammasomes in sexually transmitted infections is mostly drawn from results obtained in vitro, from distant infection sites, or from related microbial strains that are not sexually transmitted. Understanding how inflammasomes influence the outcome of sexually transmitted infections may lead to the development of novel and effective strategies to control disease and prevent transmission. Here, we discuss and highlight the recent progress in this field.
Issue Date: 31-Aug-2016
Date of Acceptance: 5-Aug-2016
URI: http://hdl.handle.net/10044/1/39728
DOI: https://dx.doi.org/10.1016/j.it.2016.08.004
ISSN: 1471-4981
Publisher: Elsevier (Cell Press)
Start Page: 703
End Page: 714
Journal / Book Title: Trends in Immunology
Volume: 37
Issue: 10
Copyright Statement: © 2016 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Sponsor/Funder: The Royal Society
Wellcome Trust
Funder's Grant Number: N/A
Keywords: Immunology
1107 Immunology
Publication Status: Published
Appears in Collections:Department of Medicine (up to 2019)