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Real-time detection of carboplatin using a microfluidic system

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Title: Real-time detection of carboplatin using a microfluidic system
Authors: Phairatana, T
Leong, CL
Gowers, SAN
Patel, BA
Boutelle, MG
Item Type: Journal Article
Abstract: A microfluidic sensor system based on a carbon nanotube-epoxy composite electrode was fabricated to allow detection of the presence of the anti-cancer drug carboplatin in healthy tissue in real time during chemotherapy. Detection of carboplatin was carried out by observing the effects of the drug on the differential pulse voltammetry of free purine bases using a novel carbon nanotube-epoxy composite electrode. In free solution these electrodes performed better than glassy carbon electrodes for oxidation of the free purine bases AMP and GMP, and than DNA-modified carbon nanotube-epoxy composite sensors for detection of carboplatin. On-line carboplatin detection was performed using a computer-controlled microfluidic platform. The methodology for on-line carboplatin detection was optimised in terms of the analysis time and of to allow repeated carboplatin measurement using the same electrode. Microdialysis sampling and our microfluidic platform were combined to give a proof of concept system for real-time carboplatin detection with a limit of detection of 0.014 mM carboplatin in the sampled media. This paper is dedicated to Craig Lunte’s pioneering work in analysis and microdialysis.
Issue Date: 26-Aug-2016
Date of Acceptance: 26-Aug-2016
URI: http://hdl.handle.net/10044/1/39526
DOI: 10.1039/C6AN01446A
ISSN: 0003-2654
Publisher: Royal Society of Chemistry
Start Page: 6270
End Page: 6277
Journal / Book Title: Analyst
Volume: 141
Copyright Statement: © The Royal Society of Chemistry 2016. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (https://creativecommons.org/licenses/by/3.0/)
Keywords: Analytical Chemistry
0301 Analytical Chemistry
0399 Other Chemical Sciences
Publication Status: Accepted
Appears in Collections:Bioengineering
Faculty of Engineering