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Proliferation, survival and metabolism: the role of PI3K/AKT/mTOR signalling in pluripotency and cell fate determination

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Title: Proliferation, survival and metabolism: the role of PI3K/AKT/mTOR signalling in pluripotency and cell fate determination
Authors: Cui, W
Yu, J
Item Type: Journal Article
Abstract: Phosphatidylinositide 3 kinases (PI3Ks) and their downstream mediators AKT and mammalian target of rapamycin (mTOR) constitute the core components of the PI3K/AKT/mTOR signalling cascade, regulating cell proliferation, survival and metabolism. Although these functions are well defined in the context of tumorigenesis, recent studies – in particular those using pluripotent stem cells – have highlighted the importance of this pathway to development and cellular differentiation. Here we review the recent in vitro and in vivo evidence for the role PI3K/Akt/mTOR signalling plays in the control of pluripotency and differentiation, with a particular focus on the molecular mechanisms underlying these functions.
Issue Date: 30-Aug-2016
Date of Acceptance: 22-Jul-2016
URI: http://hdl.handle.net/10044/1/38903
DOI: https://dx.doi.org/10.1242/dev.137075
ISSN: 0950-1991
Publisher: Company of Biologists
Start Page: 3050
End Page: 3060
Journal / Book Title: Development
Volume: 143
Copyright Statement: © 2016. Published by The Company of Biologists Ltd
Keywords: AKT
Metabolism
PI3K
Pluripotency
Proliferation and differentiation
mTOR
06 Biological Sciences
11 Medical And Health Sciences
Publication Status: Published
Appears in Collections:Department of Surgery and Cancer