A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease

Title: A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease
Authors: Scott, RA
Freitag, DF
Li, L
Chu, AY
Surendran, P
Young, R
Grarup, N
Stancakova, A
Chen, Y
Varga, TV
Yaghootkar, H
Luan, J
Zhao, JH
Willems, SM
Wessel, J
Wang, S
Maruthur, N
Michailidou, K
Pirie, A
Van der Lee, SJ
Gillson, C
Al Olama, AA
Amouyel, P
Arriola, L
Arveiler, D
Aviles-Olmos, I
Balkau, B
Barricarte, A
Barroso, I
Garcia, SB
Bis, JC
Blankenberg, S
Boehnke, M
Boeing, H
Boerwinkle, E
Borecki, IB
Bork-Jensen, J
Bowden, S
Caldas, C
Caslake, M
Cupples, LA
Cruchaga, C
Czajkowski, J
Den Hoed, M
Dunn, JA
Earl, HM
Ehret, GB
Ferrannini, E
Ferrieres, J
Foltynie, T
Ford, I
Forouhi, NG
Gianfagna, F
Gonzalez, C
Grioni, S
Hiller, L
Jansson, J-H
Jorgensen, ME
Jukema, JW
Kaaks, R
Kee, F
Kerrison, ND
Key, TJ
Kontto, J
Kote-Jarai, Z
Kraja, AT
Kuulasmaa, K
Kuusisto, J
Linneberg, A
Liu, C
Marenne, G
Mohlke, KL
Morris, AP
Muir, K
Mueller-Nurasyid, M
Munroe, PB
Navarro, C
Nielsen, SF
Nilsson, PM
Nordestgaard, BG
Packard, CJ
Palli, D
Panico, S
Peloso, GM
Perola, M
Peters, A
Poole, CJ
Quiros, JR
Rolandsson, O
Sacerdote, C
Salomaa, V
Sanchez, M-J
Sattar, N
Sharp, SJ
Sims, R
Slimani, N
Smith, JA
Thompson, DJ
Trompet, S
Tumino, R
Van der A, DL
Van der Schouw, YT
Virtamo, J
Walker, M
Walter, K
Abraham, JE
Amundadottir, LT
Aponte, JL
Butterworth, A
Dupuis, J
Easton, DF
Eeles, RA
Erdmann, J
Franks, PW
Frayling, TM
Hansen, T
Howson, JMM
Jorgensen, T
Kooner, J
Laakso, M
Langenberg, C
McCarthy, MI
Pankow, JS
Pedersen, O
Riboli, E
Rotter, JI
Saleheen, D
Samani, NJ
Schunkert, H
Vollenweider, P
O'Rahilly, S
Deloukas, P
Danesh, J
Goodarzi, MO
Kathiresan, S
Meigs, JB
Ehm, MG
Wareham, NJ
Waterworth, DM
Item Type: Journal Article
Issue Date: 1-Jun-2016
Date of Acceptance: 10-May-2016
URI: http://hdl.handle.net/10044/1/38461
DOI: http://dx.doi.org/10.1126/scitranslmed.aad3744
ISSN: 1946-6242
Publisher: American Association for the Advancement of Science
Start Page: 341ra76
End Page: 341ra76
Journal / Book Title: Science Translational Medicine
Volume: 8
Issue: 341
Copyright Statement: This is the author accepted manuscript. The final version is available from the American Association for the Advancement of Science via http://dx.doi.org/10.1126/scitranslmed.aad3744
Keywords: Science & Technology
Life Sciences & Biomedicine
Cell Biology
Medicine, Research & Experimental
Research & Experimental Medicine
GLUCAGON-LIKE PEPTIDE-1
TYPE-2 DIABETES-MELLITUS
PLACEBO-CONTROLLED TRIAL
RECEPTOR AGONIST LIXISENATIDE
ONCE-DAILY LIXISENATIDE
RANDOMIZED CONTROLLED-TRIAL
INCRETIN-BASED THERAPIES
BETA-CELL FUNCTION
BODY-MASS INDEX
DOUBLE-BLIND
CVD50 consortium
GERAD_EC Consortium
Neurology Working Group of the Cohorts for Heart
Aging Research in Genomic Epidemiology (CHARGE)
Alzheimer’s Disease Genetics Consortium
Pancreatic Cancer Cohort Consortium
European Prospective Investigation into Cancer and Nutrition–Cardiovascular Disease (EPIC-CVD)
EPIC-InterAct
CHARGE consortium
CHD Exome+ Consortium
CARDIOGRAM Exome Consortium
11 Medical And Health Sciences
06 Biological Sciences
Publication Status: Published
Open Access location: https://www.repository.cam.ac.uk/handle/1810/256264
Appears in Collections:School of Public Health