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Reduced efficacy of praziquantel against Schistosoma mansoni is associated with multiple-rounds of mass drug administration

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Title: Reduced efficacy of praziquantel against Schistosoma mansoni is associated with multiple-rounds of mass drug administration
Authors: Crellen, T
Walker, M
Cotton, JA
Lamberton, PHL
Webster, JP
Tukahebwa, EM
Kabatereine, NB
Item Type: Journal Article
Abstract: The efficacy of praziquantel against Schistosoma mansoni was significantly lower in Ugandan schools that had received more prior rounds of mass drug administration, as determined by fitting a statistical model to parasite egg counts before and after treatment.
Issue Date: 28-Jul-2016
Date of Acceptance: 21-Jul-2016
URI: http://hdl.handle.net/10044/1/38381
DOI: https://dx.doi.org/10.1093/cid/ciw506
ISSN: 1537-6591
Publisher: Oxford University Press (OUP)
Start Page: 1151
End Page: 1159
Journal / Book Title: Clinical Infectious Diseases
Volume: 63
Issue: 9
Copyright Statement: © The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Sponsor/Funder: World Health Organization
World Health Organization (Switzerland)
Funder's Grant Number: World Health Organization
2015/540029-0
Keywords: anthelmintic efficacy
generalized linear mixed model
parasite
praziquantel
schistosomiasis
Microbiology
06 Biological Sciences
11 Medical And Health Sciences
Publication Status: Published
Appears in Collections:School of Public Health