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[18F]-FDG PET/CT characterisation of progressive HIV-associated tuberculosis
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NIHMS69229.pdf | File embargoed for 6 months after publication date | 1.27 MB | Adobe PDF | Request a copy |
NIHMS69229-supplement-Supplementary_Information.pdf | File embargoed for 6 months after publication date | 1.75 MB | Adobe PDF | Request a copy |
Title: | [18F]-FDG PET/CT characterisation of progressive HIV-associated tuberculosis |
Authors: | Wilkinson, RJ Esmail, H Lesosky, M Lai, RP Wilkinson, KA Graham, CM Coussens, AK Oni, T Warwick, J Said-Hartley, Q Koegenelburg, CF Walzl, G Flynn, JL Young, DB Barry, CE O'Garra, A |
Item Type: | Journal Article |
Abstract: | Tuberculosis is classically divided into states of latent infection and active disease. Using combined positron emission and computed tomography in 35 asymptomatic, antiretroviral therapy naïve, HIV-1 infected adults with latent tuberculosis, we identified ten individuals with pulmonary abnormalities suggestive of subclinical, active disease who were significantly more likely to progress to clinical disease. Our findings challenge the conventional two-state paradigm and may aid future identification of biomarkers predictive of progression. |
Date of Acceptance: | 8-Jul-2016 |
URI: | http://hdl.handle.net/10044/1/37409 |
ISSN: | 1546-170X |
Publisher: | Nature Publishing Group |
Journal / Book Title: | Nature Medicine |
Sponsor/Funder: | Bill & Melinda Gates Foundation Wellcome Trust Wellcome Trust Wellcome Trust |
Funder's Grant Number: | Grant Number 37882 077381/Z/05/Z 090170/Z/09/Z 104803/Z/14/ZR |
Keywords: | Immunology 11 Medical And Health Sciences |
Publication Status: | Accepted |
Appears in Collections: | Department of Medicine (up to 2019) |