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Adaptive multiphoton endomicroscopy through a dynamically deformed multicore optical fiber using proximal detection

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Title: Adaptive multiphoton endomicroscopy through a dynamically deformed multicore optical fiber using proximal detection
Authors: Warren, SC
Kim, Y
Stone, JM
Mitchell, C
Knight, JC
Neil, MAA
Paterson, C
French, PMW
Dunsby, CW
Item Type: Journal Article
Abstract: This paper demonstrates multiphoton excited fluorescence imaging through a polarisation maintaining multicore fiber (PM-MCF) while the fiber is dynamically deformed using all-proximal detection. Single-shot proximal measurement of the relative optical path lengths of all the cores of the PM-MCF in double pass is achieved using a Mach-Zehnder interferometer read out by a scientific CMOS camera operating at 416 Hz. A non-linear least squares fitting procedure is then employed to determine the deformation-induced lateral shift of the excitation spot at the distal tip of the PM-MCF. An experimental validation of this approach is presented that compares the proximally measured deformation-induced lateral shift in focal spot position to an independent distally measured ground truth. The proximal measurement of deformation-induced shift in focal spot position is applied to correct for deformation-induced shifts in focal spot position during raster-scanning multiphoton excited fluorescence imaging.
Issue Date: 19-Sep-2016
Date of Acceptance: 15-Jul-2016
URI: http://hdl.handle.net/10044/1/37107
DOI: https://dx.doi.org/10.1364/OE.24.021474
ISSN: 1094-4087
Publisher: Optical Society of America
Start Page: 21474
End Page: 21484
Journal / Book Title: Optics Express
Volume: 24
Issue: 19
Copyright Statement: Published by The Optical Society under the terms of the Creative Commons Attribution 4.0 License. Further distribution of this work must maintain attribution to the author(s) and the published article’s title, journal citation, and DOI.
Sponsor/Funder: Engineering & Physical Science Research Council (EPSRC)
Funder's Grant Number: EP/K020102/1
Keywords: Optics
0205 Optical Physics
1005 Communications Technologies
0906 Electrical And Electronic Engineering
Publication Status: Published
Appears in Collections:Physics
Faculty of Natural Sciences