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An update of the WCRF/AICR systematic literature review on esophageal and gastric cancers and citrus fruits intake.

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Title: An update of the WCRF/AICR systematic literature review on esophageal and gastric cancers and citrus fruits intake.
Authors: Vingeliene, S
Chan, DS
Aune, D
Vieira, AR
Polemiti, E
Stevens, C
Abar, L
Rosenblatt, DN
Greenwood, DC
Norat, T
Item Type: Journal Article
Abstract: The 2007 World Cancer Research Fund/American Institute for Cancer Research expert report concluded that foods containing vitamin C probably protect against esophageal cancer and fruits probably protect against gastric cancer. Most of the previous evidence was from case-control studies, which may be affected by recall and selection biases. More recently, several cohort studies have examined these associations. We conducted a systematic literature review of prospective studies on citrus fruits intake and risk of esophageal and gastric cancers.PubMed was searched for studies published until 1 March 2016. We calculated summary relative risks and 95 % confidence intervals (95 % CI) using random-effects models.With each 100 g/day increase of citrus fruits intake, a marginally significant decreased risk of esophageal cancer was observed (summary RR 0.86, 95 % CI 0.74-1.00, 1,057 cases, six studies). The associations were similar for squamous cell carcinoma (RR 0.87, 95 % CI 0.69-1.08, three studies) and esophageal adenocarcinoma (RR 0.93, 95 % CI 0.78-1.11, three studies). For gastric cancer, the nonsignificant inverse association was observed for gastric cardia cancer (RR 0.75, 95 % CI 0.55-1.01, three studies), but not for gastric non-cardia cancer (RR 1.02, 95 % CI 0.90-1.16, four studies). Consistent summary inverse associations were observed when comparing the highest with lowest intake, with statistically significant associations for esophageal (RR 0.77, 95 % CI 0.64-0.91, seven studies) and gastric cardia cancers (RR 0.62, 95 % CI 0.39-0.99, three studies).Citrus fruits may decrease the risk of esophageal and gastric cardia cancers, but further studies are needed.
Issue Date: 6-May-2016
Date of Acceptance: 27-Apr-2016
URI: http://hdl.handle.net/10044/1/34452
DOI: https://dx.doi.org/10.1007/s10552-016-0755-0
ISSN: 1573-7225
Publisher: Springer Verlag (Germany)
Start Page: 837
End Page: 851
Journal / Book Title: Cancer Causes & Control
Volume: 27
Issue: 7
Copyright Statement: © The Author(s) 2016. This article is published with open access at Springerlink.com
Sponsor/Funder: World Cancer Research Fund International
Funder's Grant Number: 2007/SP01
Keywords: Citrus fruits
Esophageal cancer
Gastric cancer
Systematic literature review
Public Health And Health Services
Oncology And Carcinogenesis
Publication Status: Published
Appears in Collections:School of Public Health