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IL-13 from intraepithelial lymphocytes regulates tissue homeostasis and protects against carcinogenesis in the skin
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Title: | IL-13 from intraepithelial lymphocytes regulates tissue homeostasis and protects against carcinogenesis in the skin |
Authors: | Dalessandri, T Crawford, G Hayes, M Castro Seoane, R Strid, J |
Item Type: | Journal Article |
Abstract: | The skin is under constant renewal and exposure to environmental challenges. How homeostasis is maintained alongside protective mechanisms against damage is unclear. Among the basal epithelial cells (ECs) is a population of resident intraepithelial lymphocytes (IELs) that provide host-protective immune surveillance. Here we show that IELs cross-communicate with ECs via the production of IL-13. Skin ECs are activated by IEL-derived IL-13, enabling a canonical EC stress response. In the absence of IL-13, or canonical IEL, the skin has decreased ability to repair its barrier and increased susceptibility to cutaneous carcinogenesis. IL-13 controls the rate of EC movement through the epidermis, which might explain the importance of IL-13 for epidermal integrity and its suppressive effect on skin carcinogenesis. These findings show that IL-13 acts as a molecular bridge between IELs and ECs, and reveal a critical host-defensive role for type-2 immunity in regulating EC tissue homeostasis and carcinogenesis. |
Issue Date: | 30-Jun-2016 |
Date of Acceptance: | 26-May-2016 |
URI: | http://hdl.handle.net/10044/1/34277 |
DOI: | 10.1038/ncomms12080 |
ISSN: | 2041-1723 |
Publisher: | Nature Publishing Group |
Start Page: | 1 |
End Page: | 12 |
Journal / Book Title: | Nature Communications |
Volume: | 7 |
Copyright Statement: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
Sponsor/Funder: | Wellcome Trust |
Funder's Grant Number: | 100999/Z/13/Z |
Keywords: | Science & Technology Multidisciplinary Sciences Science & Technology - Other Topics DELTA T-CELLS THYMIC STROMAL LYMPHOPOIETIN LYMPHOID STRESS-SURVEILLANCE TERMINAL DIFFERENTIATION BIOLOGICAL APPROACH ATOPIC-DERMATITIS TYPE-2 IMMUNITY CANCER GAMMA INFLAMMATION Animals Cytokines Epithelial Cells Homeostasis Interleukin-13 Interleukin-33 Intraepithelial Lymphocytes Mice, Inbred BALB C Skin Skin Neoplasms Epithelial Cells Skin Animals Mice, Inbred BALB C Skin Neoplasms Interleukin-13 Cytokines Homeostasis Interleukin-33 Intraepithelial Lymphocytes |
Publication Status: | Published |
Article Number: | 12080 |
Online Publication Date: | 2016-06-30 |
Appears in Collections: | Department of Immunology and Inflammation Department of Metabolism, Digestion and Reproduction Faculty of Medicine |