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IL-13 from intraepithelial lymphocytes regulates tissue homeostasis and protects against carcinogenesis in the skin

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Title: IL-13 from intraepithelial lymphocytes regulates tissue homeostasis and protects against carcinogenesis in the skin
Authors: Dalessandri, T
Crawford, G
Hayes, M
Castro Seoane, R
Strid, J
Item Type: Journal Article
Abstract: The skin is under constant renewal and exposure to environmental challenges. How homeostasis is maintained alongside protective mechanisms against damage is unclear. Among the basal epithelial cells (ECs) is a population of resident intraepithelial lymphocytes (IELs) that provide host-protective immune surveillance. Here we show that IELs cross-communicate with ECs via the production of IL-13. Skin ECs are activated by IEL-derived IL-13, enabling a canonical EC stress response. In the absence of IL-13, or canonical IEL, the skin has decreased ability to repair its barrier and increased susceptibility to cutaneous carcinogenesis. IL-13 controls the rate of EC movement through the epidermis, which might explain the importance of IL-13 for epidermal integrity and its suppressive effect on skin carcinogenesis. These findings show that IL-13 acts as a molecular bridge between IELs and ECs, and reveal a critical host-defensive role for type-2 immunity in regulating EC tissue homeostasis and carcinogenesis.
Issue Date: 30-Jun-2016
Date of Acceptance: 26-May-2016
URI: http://hdl.handle.net/10044/1/34277
DOI: 10.1038/ncomms12080
ISSN: 2041-1723
Publisher: Nature Publishing Group
Start Page: 1
End Page: 12
Journal / Book Title: Nature Communications
Volume: 7
Copyright Statement: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Sponsor/Funder: Wellcome Trust
Funder's Grant Number: 100999/Z/13/Z
Keywords: Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
DELTA T-CELLS
THYMIC STROMAL LYMPHOPOIETIN
LYMPHOID STRESS-SURVEILLANCE
TERMINAL DIFFERENTIATION
BIOLOGICAL APPROACH
ATOPIC-DERMATITIS
TYPE-2 IMMUNITY
CANCER
GAMMA
INFLAMMATION
Animals
Cytokines
Epithelial Cells
Homeostasis
Interleukin-13
Interleukin-33
Intraepithelial Lymphocytes
Mice, Inbred BALB C
Skin
Skin Neoplasms
Epithelial Cells
Skin
Animals
Mice, Inbred BALB C
Skin Neoplasms
Interleukin-13
Cytokines
Homeostasis
Interleukin-33
Intraepithelial Lymphocytes
Publication Status: Published
Article Number: 12080
Online Publication Date: 2016-06-30
Appears in Collections:Department of Immunology and Inflammation
Department of Metabolism, Digestion and Reproduction
Faculty of Medicine