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Remarkably low affinity of CD4/peptide-major histocompatibility complex class II protein interactions

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Title: Remarkably low affinity of CD4/peptide-major histocompatibility complex class II protein interactions
Authors: Jonsson, P
Southcombe, JH
Santos, AM
Huo, J
Fernandes, RA
McColl, J
Lever, M
Evans, EJ
Hudson, A
Chang, VT
Hanke, T
Godkin, A
Dunne, PD
Horrocks, MH
Palayret, M
Screaton, GR
Petersen, J
Rossjohn, J
Fugger, L
Dushek, O
Xu, X-N
Davis, SJ
Klenerman, D
Item Type: Journal Article
Issue Date: 17-May-2016
Date of Acceptance: 23-Mar-2016
URI: http://hdl.handle.net/10044/1/33706
DOI: https://dx.doi.org/10.1073/pnas.1513918113
ISSN: 1091-6490
Publisher: National Academy of Sciences
Start Page: 5682
End Page: 5687
Journal / Book Title: Proceedings of the National Academy of Sciences of the United States of America
Volume: 113
Issue: 20
Copyright Statement: © 2016 National Academy of Sciences.
Keywords: Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
Protein interactions
TCR phosphorylation
Adhesion
T-cell activation
Binding equilibrium
Kinetics
T-cell-receptor
Conctact-area FRAP
Crystal-structure
Antigen discrimination
Immunological synapse
Fluorescence recovery
Peptide-MHC
Molecules
Binding equilibrium and kinetics
MD Multidisciplinary
Publication Status: Published
Appears in Collections:Department of Medicine (up to 2019)