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Rabbit models of cardiac mechano-electric and mechano-mechanical coupling

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Title: Rabbit models of cardiac mechano-electric and mechano-mechanical coupling
Authors: Quinn, T
Kohl, P
Item Type: Journal Article
Abstract: Cardiac auto-regulation involves integrated regulatory loops linking electrics and mechanics in the heart. Whereas mechanical activity is usually seen as the endpoint of cardiac auto-regulation, it is important to appreciate that the heart would not function without feed-back from the mechanical environment to cardiac electrical (mechano-electric coupling, MEC) and mechanical (mechano-mechanical coupling, MMC) activity. MEC and MMC contribute to beat-by-beat adaption of cardiac output to physiological demand, and they are involved in various pathological settings, potentially aggravating cardiac dysfunction. Experimental and computational studies using rabbit as a model species have been integral to the development of our current understanding of MEC and MMC. In this paper we review this work, focusing on physiological and pathological implications for cardiac function.
Issue Date: 18-May-2016
Date of Acceptance: 1-May-2016
URI: http://hdl.handle.net/10044/1/32899
DOI: http://dx.doi.org/10.1016/j.pbiomolbio.2016.05.003
ISSN: 0079-6107
Publisher: Elsevier
Start Page: 110
End Page: 122
Journal / Book Title: Progress in Biophysics and MolecularBiology
Volume: 121
Issue: 2
Copyright Statement: © 2016 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Sponsor/Funder: British Heart Foundation
Funder's Grant Number: FS/12/17/29532
Keywords: Atrium
Electrophysiology
Heart
Mechanics
Sinoatrial node
Slow force response
Ventricle
Biophysics
0601 Biochemistry And Cell Biology
Publication Status: Published
Appears in Collections:National Heart and Lung Institute