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Two cases of possible transmitted drug-resistant HIV: likely HIV superinfection and unmasking of pre-existing resistance.

Title: Two cases of possible transmitted drug-resistant HIV: likely HIV superinfection and unmasking of pre-existing resistance.
Authors: Martin, F
Lee, J
Thomson, E
Tarrant, N
Hale, A
Lacey, CJ
Item Type: Journal Article
Abstract: © 2015, The Author(s) 2015.In the UK, patients undergo HIV viral load and genotype testing before they are prescribed antiretroviral therapy. The genotype test guides clinicians in prescribing antiretroviral therapy with maximum efficacy against the patient’s specific viral strain. HIV viral load escape under antiretroviral drug therapy, to which the virus was thought to be genotypically susceptible, is commonly observed in patients with poor adherence. We observed early viral escapes in two-newly diagnosed patients, during antiretroviral treatment, with different sequences compared to their original viral resistance test and who reported excellent adherence to and tolerance of their therapy. HIV superinfection with a new viral strain was identified in a patient with multiple risk factors and co-infections with sexually transmitted infections. The second patient was a case of the emergence of primary resistant virus under drug pressure. Both suppressed their virus promptly after treatment switch.
Issue Date: 7-Feb-2015
Date of Acceptance: 5-Jan-2015
URI: http://hdl.handle.net/10044/1/32720
DOI: https://dx.doi.org/10.1177/0956462415571671
ISSN: 1758-1052
Publisher: SAGE Publications (UK and US)
Start Page: 66
End Page: 69
Journal / Book Title: International Journal of STD & AIDS
Volume: 27
Issue: 1
Copyright Statement: This article is distributed under the terms of the Creative Commons Attribution 3.0 License (http://www.creativecommons.org/licenses/by/3.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
Sponsor/Funder: Wellcome Trust
Funder's Grant Number: 102789/Z/13/Z
Keywords: AIDS
HIV
Transmitted drug resistance
antiviral
dual infection
hepatitis C
high-risk behaviour
highly active antiretroviral therapy
minority species
superinfection
syphilis (Treponema pallidum)
viral disease
Adult
Anti-HIV Agents
Antiretroviral Therapy, Highly Active
Coinfection
Drug Resistance, Viral
Genotype
HIV Infections
HIV-1
Homosexuality, Male
Humans
Male
RNA, Viral
Superinfection
Treatment Outcome
Viral Load
Public Health
1103 Clinical Sciences
1108 Medical Microbiology
1117 Public Health And Health Services
Publication Status: Published
Appears in Collections:Department of Surgery and Cancer