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Proteome-wide dataset supporting functional study of tyrosine kinases in breast cancer.

Title: Proteome-wide dataset supporting functional study of tyrosine kinases in breast cancer.
Authors: Angelopoulos, N
Stebbing, J
Xu, Y
Giamas, G
Zhang, H
Item Type: Journal Article
Abstract: © 2016 The Authors.Tyrosine kinases (TKs) play an essential role in regulating various cellular activities and dysregulation of TK signaling contributes to oncogenesis. However, less than half of the TKs have been thoroughly studied. Through a combined use of RNAi and stable isotope labeling with amino acids in cell culture (SILAC)-based quantitative proteomics, a global functional proteomic landscape of TKs in breast cancer was recently revealed highlighting a comprehensive and highly integrated signaling network regulated by TKs (Stebbing et al., 2015) [1]. We collate the enormous amount of the proteomic data in an open access platform, providing a valuable resource for studying the function of TKs in cancer and benefiting the science community. Here we present a detailed description related to this study (Stebbing et al., 2015) [1] and the raw data have been deposited to the ProteomeXchange Consortium via the PRIDE partner repository with the identifier PXD002065.
Issue Date: 14-Mar-2016
Date of Acceptance: 4-Mar-2016
URI: http://hdl.handle.net/10044/1/30925
DOI: https://dx.doi.org/10.1016/j.dib.2016.03.024
ISSN: 2352-3409
Publisher: Elsevier
Start Page: 740
End Page: 746
Journal / Book Title: Data in Brief
Volume: 7
Copyright Statement: © 2016 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: Breast cancer
Cell signaling
Proteomics
SILAC
Tyrosine kinases
Publication Status: Published
Appears in Collections:Department of Surgery and Cancer