Oxidative stress-induced mitochondrial dysfunction drives inflammation and airway smooth muscle remodeling in patients with chronic obstructive pulmonary disease

Title:	Oxidative stress-induced mitochondrial dysfunction drives inflammation and airway smooth muscle remodeling in patients with chronic obstructive pulmonary disease
Authors:	Wiegman, CH Michaeloudes, C Haji, G Narang, P Clarke, CJ Russell, KE Bao, W Pavlidis, S Barnes, PJ Kanerva, J Bittner, A Rao, N Murphy, MP Kirkham, PA Chung, KF Adcock, IM
Item Type:	Journal Article
Issue Date:	1-Sep-2015
Date of Acceptance:	30-Jan-2015
URI:	http://hdl.handle.net/10044/1/29981
DOI:	http://dx.doi.org/10.1016/j.jaci.2015.01.046
ISSN:	1097-6825
Publisher:	Elsevier
Start Page:	769
End Page:	780
Journal / Book Title:	Journal of Allergy and Clinical Immunology
Volume:	136
Issue:	3
Copyright Statement:	© 2015 The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords:	Science & Technology Life Sciences & Biomedicine Allergy Immunology Ozone inflammation airway smooth muscle mitochondria chronic obstructive pulmonary disease airway hyperresponsiveness oxidative stress antioxidant proliferation MitoQ ENERGY-METABOLISM ASTHMA FEATURES ALLERGIC-ASTHMA MURINE MODEL OZONE CELLS COPD MECHANISMS IMMUNITY BETA Adult Aged Airway Remodeling Animals Antioxidants Bronchial Hyperreactivity Electron Transport Chain Complex Proteins Female Gene Expression Regulation Humans Hydrogen Peroxide Male Membrane Potential, Mitochondrial Mice Middle Aged Mitochondria Muscle, Smooth Myocytes, Smooth Muscle Organophosphorus Compounds Oxidative Stress Pneumonia Pulmonary Disease, Chronic Obstructive Reactive Oxygen Species Respiratory System Signal Transduction Smoking Ubiquinone COPDMAP 1107 Immunology
Publication Status:	Published
Appears in Collections:	Computing National Heart and Lung Institute Faculty of Engineering