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The peptide-binding cavity Is essential for Als3-mediated adhesion of Candida albicans to human cells
| File | Description | Size | Format | |
|---|---|---|---|---|
 lin14jbc.pdf | Published version | 2.89 MB | Adobe PDF | View/Open |
| Title: | The peptide-binding cavity Is essential for Als3-mediated adhesion of Candida albicans to human cells |
| Authors: | Lin, J Oh, S-H Jones, R Garnett, JA Salgado, PS Rusnakova, S Matthews, SJ Hoyer, LL Cota, E |
| Item Type: | Journal Article |
| Abstract: | Background: Of the eight cell surface glycoproteins in the C. albicans Als family, Als3 makes the largest contribution to adhesion to human cells. Results: Mutation of the Als3 peptide-binding cavity (PBC) results in loss of Als3 adhesive function. Conclusion: The PBC is required for Als3 adhesive function. Significance: Interfering with PBC function is a viable strategy for inhibiting C. albicans adhesion. |
| Issue Date: | 27-Jun-2014 |
| Date of Acceptance: | 6-May-2014 |
| URI: | http://hdl.handle.net/10044/1/29746 |
| DOI: | 10.1074/jbc.M114.547877 |
| ISSN: | 1083-351X |
| Publisher: | American Society for Biochemistry and Molecular Biology |
| Start Page: | 18401 |
| End Page: | 18412 |
| Journal / Book Title: | Journal of Biological Chemistry |
| Volume: | 289 |
| Issue: | 26 |
| Copyright Statement: | © 2014 by The American Society for Biochemistry and Molecular Biology, Inc. Free via Creative Commons: CC-BY license |
| Sponsor/Funder: | Wellcome Trust Biotechnology and Biological Sciences Research Council (BBSRC) |
| Funder's Grant Number: | 085464/Z/08/Z BB/K003887/1 |
| Keywords: | Science & Technology Life Sciences & Biomedicine Biochemistry & Molecular Biology BIOCHEMISTRY & MOLECULAR BIOLOGY BIOFILM FORMATION ALS FAMILY PROTEIN GENE EPIDEMIOLOGY SPECIFICITY SEQUENCE SURVEILLANCE LIGANDS Science & Technology Life Sciences & Biomedicine Biochemistry & Molecular Biology BIOFILM FORMATION ALS FAMILY PROTEIN GENE EPIDEMIOLOGY SPECIFICITY SEQUENCE SURVEILLANCE LIGANDS Adhesion Aggregation Als Adhesins Candida albicans Functional Amyloid Nuclear Magnetic Resonance (NMR) Peptide-binding Cavity Peptide-binding Protein X-ray Crystallography Candida albicans Candidiasis Crystallography, X-Ray Endothelial Cells Fungal Proteins Humans Models, Molecular Protein Structure, Tertiary Endothelial Cells Humans Candida albicans Candidiasis Fungal Proteins Crystallography, X-Ray Protein Structure, Tertiary Models, Molecular 03 Chemical Sciences 06 Biological Sciences 11 Medical and Health Sciences Biochemistry & Molecular Biology |
| Publication Status: | Published |
| Online Publication Date: | 2021-01-04 |
| Appears in Collections: | Faculty of Natural Sciences |