Whole Genome Sequence Analysis Suggests Intratumoral Heterogeneity in Dissemination of Breast Cancer to Lymph Nodes

Title:	Whole Genome Sequence Analysis Suggests Intratumoral Heterogeneity in Dissemination of Breast Cancer to Lymph Nodes
Authors:	Blighe, K Kenny, L Patel, N Guttery, DS Page, K Gronau, JH Golshani, C Stebbing, J Coombes, RC Shaw, JA
Item Type:	Journal Article
Issue Date:	29-Dec-2014
Date of Acceptance:	22-Nov-2014
URI:	http://hdl.handle.net/10044/1/29186
DOI:	https://dx.doi.org/10.1371/journal.pone.0115346
ISSN:	1932-6203
Publisher:	Public Library of Science
Journal / Book Title:	PLOS One
Volume:	9
Issue:	12
Copyright Statement:	© 2014 Blighe et al. This is an openaccess article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Sponsor/Funder:	National Institute for Health Research Cancer Research UK
Funder's Grant Number:	NIHR-RP-011-053 C27532/A14549
Keywords:	Science & Technology Multidisciplinary Sciences Science & Technology - Other Topics CHROMOSOMAL INSTABILITY GENE-EXPRESSION CLINICAL-IMPLICATIONS CLONAL EVOLUTION TP53 MUTATIONS OVEREXPRESSION METASTASIS CARCINOMAS REVEALS DISEASE Adaptor Proteins, Signal Transducing Antigens, Neoplasm Breast Neoplasms Cyclin B2 DNA Topoisomerases, Type II DNA-Binding Proteins Female GTPase-Activating Proteins Genetic Heterogeneity Genome, Human Homeodomain Proteins Humans Lymphatic Metastasis Polymorphism, Single Nucleotide Repressor Proteins Transcription Factors Tumor Suppressor Protein p53 General Science & Technology MD Multidisciplinary
Publication Status:	Published
Article Number:	e115346
Appears in Collections:	Department of Surgery and Cancer