A Genome-Wide Association Meta-Analysis of Circulating Sex Hormone-Binding Globulin Reveals Multiple Loci Implicated in Sex Steroid Hormone Regulation

Title:	A Genome-Wide Association Meta-Analysis of Circulating Sex Hormone-Binding Globulin Reveals Multiple Loci Implicated in Sex Steroid Hormone Regulation
Authors:	Coviello, AD Haring, R Wellons, M Vaidya, D Lehtimaki, T Keildson, S Lunetta, KL He, C Fornage, M Lagou, V Mangino, M Onland-Moret, NC Chen, B Eriksson, J Garcia, M Mei, Y Koster, A Lohman, K Lyytikainen, L-P Petersen, A-K Prescott, J Stolk, L Vandenput, L Wood, AR Zhuang, WV Ruokonen, A Hartikainen, A-L Pouta, A Bandinelli, S Biffar, R Brabant, G Cox, DG Chen, Y Cummings, S Ferrucci, L Gunter, MJ Hankinson, SE Martikainen, H Hofman, A Homuth, G Illig, T Jansson, J-O Johnson, AD Karasik, D Karlsson, M Kettunen, J Kiel, DP Kraft, P Liu, J Ljunggren, O Lorentzon, M Maggio, M Markus, MRP Mellstrom, D Miljkovic, I Mirel, D Nelson, S Papunen, LM Peeters, PHM Prokopenko, I Raffel, L Reincke, M Reiner, AP Rexrode, K Rivadeneira, F Schwartz, SM Siscovick, D Soranzo, N Stockl, D Tworoger, S Uitterlinden, AG Van Gils, CH Vasan, RS Wichmann, H-E Zhai, G Bhasin, S Bidlingmaier, M Chanock, SJ De Vivo, I Harris, TB Hunter, DJ Kahonen, M Liu, S Ouyang, P Spector, TD Van der Schouw, YT Viikari, J Wallaschofski, H McCarthy, MI Frayling, TM Murray, A Franks, S Jarvelin, M-R De Jong, FH Raitakari, O Teumer, A Ohlsson, C Murabito, JM Perry, JRB
Item Type:	Journal Article
Issue Date:	1-Jul-2012
Date of Acceptance:	19-May-2012
URI:	http://hdl.handle.net/10044/1/28751
DOI:	https://dx.doi.org/10.1371/journal.pgen.1002805
ISSN:	1553-7390
Publisher:	Public Library of Science
Journal / Book Title:	PLOS Genetics
Volume:	8
Issue:	7
Copyright Statement:	This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.
Sponsor/Funder:	Medical Research Council (MRC) Medical Research Council (MRC)
Funder's Grant Number:	G0801056B G0802782
Keywords:	Science & Technology Life Sciences & Biomedicine Genetics & Heredity GENETICS & HEREDITY POLYCYSTIC-OVARY-SYNDROME RECEPTOR TYROSINE KINASE HAN CHINESE POPULATION INSULIN-RECEPTOR GENE-EXPRESSION SHBG GENE MEDICAL PROGRESS GCKR RS780094 RISK POLYMORPHISM Alleles Female Genetic Heterogeneity Genome-Wide Association Study Gonadal Steroid Hormones Humans Male Metabolic Networks and Pathways Polymorphism, Single Nucleotide Sex Characteristics Sex Hormone-Binding Globulin Developmental Biology 0604 Genetics
Publication Status:	Published
Article Number:	e1002805
Appears in Collections:	Department of Surgery and Cancer