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A Genome-Wide Association Meta-Analysis of Circulating Sex Hormone-Binding Globulin Reveals Multiple Loci Implicated in Sex Steroid Hormone Regulation

Title: A Genome-Wide Association Meta-Analysis of Circulating Sex Hormone-Binding Globulin Reveals Multiple Loci Implicated in Sex Steroid Hormone Regulation
Authors: Coviello, AD
Haring, R
Wellons, M
Vaidya, D
Lehtimaki, T
Keildson, S
Lunetta, KL
He, C
Fornage, M
Lagou, V
Mangino, M
Onland-Moret, NC
Chen, B
Eriksson, J
Garcia, M
Mei, Y
Koster, A
Lohman, K
Lyytikainen, L-P
Petersen, A-K
Prescott, J
Stolk, L
Vandenput, L
Wood, AR
Zhuang, WV
Ruokonen, A
Hartikainen, A-L
Pouta, A
Bandinelli, S
Biffar, R
Brabant, G
Cox, DG
Chen, Y
Cummings, S
Ferrucci, L
Gunter, MJ
Hankinson, SE
Martikainen, H
Hofman, A
Homuth, G
Illig, T
Jansson, J-O
Johnson, AD
Karasik, D
Karlsson, M
Kettunen, J
Kiel, DP
Kraft, P
Liu, J
Ljunggren, O
Lorentzon, M
Maggio, M
Markus, MRP
Mellstrom, D
Miljkovic, I
Mirel, D
Nelson, S
Papunen, LM
Peeters, PHM
Prokopenko, I
Raffel, L
Reincke, M
Reiner, AP
Rexrode, K
Rivadeneira, F
Schwartz, SM
Siscovick, D
Soranzo, N
Stockl, D
Tworoger, S
Uitterlinden, AG
Van Gils, CH
Vasan, RS
Wichmann, H-E
Zhai, G
Bhasin, S
Bidlingmaier, M
Chanock, SJ
De Vivo, I
Harris, TB
Hunter, DJ
Kahonen, M
Liu, S
Ouyang, P
Spector, TD
Van der Schouw, YT
Viikari, J
Wallaschofski, H
McCarthy, MI
Frayling, TM
Murray, A
Franks, S
Jarvelin, M-R
De Jong, FH
Raitakari, O
Teumer, A
Ohlsson, C
Murabito, JM
Perry, JRB
Item Type: Journal Article
Issue Date: 1-Jul-2012
Date of Acceptance: 19-May-2012
URI: http://hdl.handle.net/10044/1/28751
DOI: https://dx.doi.org/10.1371/journal.pgen.1002805
ISSN: 1553-7390
Publisher: Public Library of Science
Journal / Book Title: PLOS Genetics
Volume: 8
Issue: 7
Copyright Statement: This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.
Sponsor/Funder: Medical Research Council (MRC)
Medical Research Council (MRC)
Funder's Grant Number: G0801056B
G0802782
Keywords: Science & Technology
Life Sciences & Biomedicine
Genetics & Heredity
GENETICS & HEREDITY
POLYCYSTIC-OVARY-SYNDROME
RECEPTOR TYROSINE KINASE
HAN CHINESE POPULATION
INSULIN-RECEPTOR
GENE-EXPRESSION
SHBG GENE
MEDICAL PROGRESS
GCKR RS780094
RISK
POLYMORPHISM
Alleles
Female
Genetic Heterogeneity
Genome-Wide Association Study
Gonadal Steroid Hormones
Humans
Male
Metabolic Networks and Pathways
Polymorphism, Single Nucleotide
Sex Characteristics
Sex Hormone-Binding Globulin
Developmental Biology
0604 Genetics
Publication Status: Published
Article Number: e1002805
Appears in Collections:Department of Surgery and Cancer