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G-Protein coupled receptor signalling in pluripotent stem cell-derived cardiovascular cells: Implications for disease modelling

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153250_Harding_ProvisionalPDF.pdfAccepted version2.94 MBAdobe PDFView/Open
2015-0039042-3.pdfSupporting information40.38 kBAdobe PDFView/Open
fcell-03-00076.pdfPublished version1.74 MBAdobe PDFView/Open
Title: G-Protein coupled receptor signalling in pluripotent stem cell-derived cardiovascular cells: Implications for disease modelling
Authors: Dolatshad, NF
Hellen, N
Jabbour, R
Harding, SE
Foldes, G
Item Type: Journal Article
Abstract: Human pluripotent stem cell derivatives show promise as an in vitro platform to study a range of human cardiovascular diseases. A better understanding of the biology of stem cells and their cardiovascular derivatives will help to understand the strengths and limitations of this new model system. G-protein coupled receptors (GPCRs) are key regulators of stem cell maintenance and differentiation and have an important role in cardiovascular cell signaling. In this review, we will therefore describe the state of knowledge concerning the regulatory role of GPCRs in both the generation and function of pluripotent stem cell derived-cardiomyocytes, -endothelial, and -vascular smooth muscle cells. We will consider how far the in vitro disease models recapitulate authentic GPCR signaling and provide a useful basis for discovery of disease mechanisms or design of therapeutic strategies.
Issue Date: 9-Dec-2015
Date of Acceptance: 9-Nov-2015
URI: http://hdl.handle.net/10044/1/28393
DOI: https://dx.doi.org/10.3389/fcell.2015.00076
ISSN: 2296-634X
Publisher: Frontiers
Journal / Book Title: Frontiers in Cell and Developmental Biology
Volume: 3
Copyright Statement: © 2015 Dolatshad, Hellen, Jabbour, Harding and Földes. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Publication Status: Published
Article Number: 76
Appears in Collections:National Heart and Lung Institute