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Skeletal muscle adiposity is associated with physical activity, exercise capacity and fibre shift in COPD

Title: Skeletal muscle adiposity is associated with physical activity, exercise capacity and fibre shift in COPD
Authors: Maddocks, M
Shrikrishna, D
Vitoriano, S
Natanek, SA
Tanner, RJ
Hart, N
Kemp, PR
Moxham, J
Polkey, MI
Hopkinson, NS
Item Type: Journal Article
Abstract: Quadriceps muscle phenotype varies widely between patients with chronic obstructive pulmonary disease (COPD) and cannot be determined without muscle biopsy. We hypothesised that measures of skeletal muscle adiposity could provide noninvasive biomarkers of muscle quality in this population. In 101 patients and 10 age-matched healthy controls, mid-thigh cross-sectional area, percentage intramuscular fat and skeletal muscle attenuation were calculated using computed tomography images and standard tissue attenuation ranges: fat -190– -30 HU; skeletal muscle -29–150 HU. Mean±sd percentage intramuscular fat was higher in the patient group (6.7±3.5% versus 4.3±1.2%, p = 0.03). Both percentage intramuscular fat and skeletal muscle attenuation were associated with physical activity level, exercise capacity and type I fibre proportion, independent of age, mid-thigh cross-sectional area and quadriceps strength. Combined with transfer factor of the lung for carbon monoxide, these variables could identify >80% of patients with fibre type shift with >65% specificity (area under the curve 0.83, 95% CI 0.72–0.95). Skeletal muscle adiposity assessed by computed tomography reflects multiple aspects of COPD related muscle dysfunction and may help to identify patients for trials of interventions targeted at specific muscle phenotypes.
Issue Date: 31-Oct-2014
Date of Acceptance: 23-May-2014
URI: http://hdl.handle.net/10044/1/23456
DOI: 10.1183/09031936.00066414
ISSN: 1399-3003
Publisher: European Respiratory Society
Start Page: 1188
End Page: 1198
Journal / Book Title: European Respiratory Journal
Volume: 44
Issue: 5
Copyright Statement: © ERS 2014. ERJ Open articles are open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0.
Sponsor/Funder: Medical Research Council (MRC)
Funder's Grant Number: G0701628
Keywords: Science & Technology
Life Sciences & Biomedicine
Respiratory System
OBSTRUCTIVE PULMONARY-DISEASE
CROSS-SECTIONAL AREA
INSULIN SENSITIVITY
COMPUTED-TOMOGRAPHY
THIGH MUSCLE
QUADRICEPS STRENGTH
VASTUS LATERALIS
BODY-COMPOSITION
HEALTH
ATTENUATION
Adipose Tissue
Adiposity
Aged
Biomarkers
Carbon Monoxide
Case-Control Studies
Exercise
Exercise Tolerance
Female
Humans
Male
Middle Aged
Motor Activity
Muscle Strength
Muscle, Skeletal
Observer Variation
Phenotype
Pulmonary Disease, Chronic Obstructive
Quadriceps Muscle
Reproducibility of Results
Sensitivity and Specificity
Tomography, X-Ray Computed
Muscle, Skeletal
Adipose Tissue
Humans
Pulmonary Disease, Chronic Obstructive
Carbon Monoxide
Observer Variation
Tomography, X-Ray Computed
Exercise
Sensitivity and Specificity
Case-Control Studies
Reproducibility of Results
Motor Activity
Exercise Tolerance
Phenotype
Aged
Middle Aged
Female
Male
Adiposity
Quadriceps Muscle
Muscle Strength
Biomarkers
Science & Technology
Life Sciences & Biomedicine
Respiratory System
OBSTRUCTIVE PULMONARY-DISEASE
CROSS-SECTIONAL AREA
COMPUTED-TOMOGRAPHY
BODY-COMPOSITION
INSULIN SENSITIVITY
THIGH MUSCLE
QUADRICEPS STRENGTH
VASTUS LATERALIS
HEALTH
ATTENUATION
11 Medical and Health Sciences
Respiratory System
Publication Status: Published
Online Publication Date: 2014-10-31
Appears in Collections:National Heart and Lung Institute
Faculty of Medicine



This item is licensed under a Creative Commons License Creative Commons