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Spatial stochastic modelling of the Hes1 gene regulatory network: intrinsic noise can explain heterogeneity in embryonic stem cell differentiation.

Title: Spatial stochastic modelling of the Hes1 gene regulatory network: intrinsic noise can explain heterogeneity in embryonic stem cell differentiation.
Authors: Sturrock, M
Hellander, A
Matzavinos, A
Chaplain, MA
Item Type: Journal Article
Abstract: Individual mouse embryonic stem cells have been found to exhibit highly variable differentiation responses under the same environmental conditions. The noisy cyclic expression of Hes1 and its downstream genes are known to be responsible for this, but the mechanism underlying this variability in expression is not well understood. In this paper, we show that the observed experimental data and diverse differentiation responses can be explained by a spatial stochastic model of the Hes1 gene regulatory network. We also propose experiments to control the precise differentiation response using drug treatment.
Issue Date: 6-Mar-2013
URI: http://hdl.handle.net/10044/1/21769
DOI: https://dx.doi.org/10.1098/rsif.2012.0988
ISSN: 1742-5689
Publisher: The Royal Society
Journal / Book Title: Journal of the Royal Society Interface
Volume: 10
Issue: 80
Copyright Statement: © 2013 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0/, which permits unrestricted use, provided the original author and source are credited.
Conference Place: England
Appears in Collections:Faculty of Natural Sciences



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