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The intraepithelial T cell response to NKG2D-ligands links lymphoid stress surveillance to atopy.
File | Description | Size | Format | |
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![]() | Accepted version | 108.12 kB | Adobe PDF | View/Open |
![]() | Supporting information | 5.56 MB | Adobe PDF | View/Open |
![]() | Supporting information | 617.03 kB | Adobe PDF | View/Open |
Title: | The intraepithelial T cell response to NKG2D-ligands links lymphoid stress surveillance to atopy. |
Authors: | Strid, J Sobolev, O Zafirova, B Polic, B Hayday, A |
Item Type: | Journal Article |
Abstract: | Epithelial cells respond to physicochemical damage with up-regulation of major histocompatibility complex-like ligands that can activate the cytolytic potential of neighboring intraepithelial T cells by binding the activating receptor, NKG2D. The systemic implications of this lymphoid stress-surveillance response, however, are unknown. We found that antigens encountered at the same time as cutaneous epithelial stress induced strong primary and secondary systemic, T helper 2 (T(H)2)-associated atopic responses in mice. These responses required NKG2D-dependent communication between dysregulated epithelial cells and tissue-associated lymphoid cells. These data are germane to uncertainty over the afferent induction of T(H)2 responses and provide a molecular framework for considering atopy as an important component of the response to tissue damage and carcinogenesis. |
Issue Date: | 2-Dec-2011 |
URI: | http://hdl.handle.net/10044/1/20028 |
DOI: | http://dx.doi.org/10.1126/science.1211250 |
Start Page: | 1293 |
End Page: | 1297 |
Journal / Book Title: | Science |
Volume: | 334 |
Issue: | 6060 |
Copyright Statement: | © 2011, American Association for the Advancement of Science. This is the author’s version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in Science on 334(6060), 2011. DOI: 10.1126/science.1211250 |
Conference Place: | United States |
Appears in Collections: | Department of Medicine (up to 2019) |