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The intraepithelial T cell response to NKG2D-ligands links lymphoid stress surveillance to atopy.

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Title: The intraepithelial T cell response to NKG2D-ligands links lymphoid stress surveillance to atopy.
Authors: Strid, J
Sobolev, O
Zafirova, B
Polic, B
Hayday, A
Item Type: Journal Article
Abstract: Epithelial cells respond to physicochemical damage with up-regulation of major histocompatibility complex-like ligands that can activate the cytolytic potential of neighboring intraepithelial T cells by binding the activating receptor, NKG2D. The systemic implications of this lymphoid stress-surveillance response, however, are unknown. We found that antigens encountered at the same time as cutaneous epithelial stress induced strong primary and secondary systemic, T helper 2 (T(H)2)-associated atopic responses in mice. These responses required NKG2D-dependent communication between dysregulated epithelial cells and tissue-associated lymphoid cells. These data are germane to uncertainty over the afferent induction of T(H)2 responses and provide a molecular framework for considering atopy as an important component of the response to tissue damage and carcinogenesis.
Issue Date: 2-Dec-2011
URI: http://hdl.handle.net/10044/1/20028
DOI: http://dx.doi.org/10.1126/science.1211250
Start Page: 1293
End Page: 1297
Journal / Book Title: Science
Volume: 334
Issue: 6060
Copyright Statement: © 2011, American Association for the Advancement of Science. This is the author’s version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in Science on 334(6060), 2011. DOI: 10.1126/science.1211250
Conference Place: United States
Appears in Collections:Department of Medicine (up to 2019)