Brain clearance is reduced during sleep and anesthesia
File(s)s41593-024-01638-y.pdf (9.16 MB)
Published version
Author(s)
Type
Journal Article
Abstract
It has been suggested that the function of sleep is to actively clear metabolites and toxins from the brain. Enhanced clearance is also said to occur during anesthesia. Here, we measure clearance and movement of fluorescent molecules in the brains of male mice and show that movement is, in fact, independent of sleep and wake or anesthesia. Moreover, we show that brain clearance is markedly reduced, not increased, during sleep and anesthesia.
Date Issued
2024-05-13
Date Acceptance
2024-04-03
Citation
Nature Neuroscience, 2024, 27, pp.1046-1050
ISSN
1097-6256
Publisher
Nature Research
Start Page
1046
End Page
1050
Journal / Book Title
Nature Neuroscience
Volume
27
Copyright Statement
© The Author(s) 2024 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
Identifier
https://www.nature.com/articles/s41593-024-01638-y
Publication Status
Published
Date Publish Online
2024-05-13