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A comparison of spectroscopy and imaging techniques utilizing spectrally resolved diffusely reflected light for intraoperative margin assessment in breast-conserving surgery: a systematic review and meta-analysis
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cancers-15-02884-v2.pdf | Published version | 3.49 MB | Adobe PDF | View/Open |
Title: | A comparison of spectroscopy and imaging techniques utilizing spectrally resolved diffusely reflected light for intraoperative margin assessment in breast-conserving surgery: a systematic review and meta-analysis |
Authors: | Shanthakumar, D Leiloglou, M Kelliher, C Darzi, A Elson, DS Leff, DR |
Item Type: | Journal Article |
Abstract: | Up to 19% of patients require re-excision surgery due to positive margins in breast-conserving surgery (BCS). Intraoperative margin assessment tools (IMAs) that incorporate tissue optical measurements could help reduce re-excision rates. This review focuses on methods that use and assess spectrally resolved diffusely reflected light for breast cancer detection in the intraoperative setting. Following PROSPERO registration (CRD42022356216), an electronic search was performed. The modalities searched for were diffuse reflectance spectroscopy (DRS), multispectral imaging (MSI), hyperspectral imaging (HSI), and spatial frequency domain imaging (SFDI). The inclusion criteria encompassed studies of human in vivo or ex vivo breast tissues, which presented data on accuracy. The exclusion criteria were contrast use, frozen samples, and other imaging adjuncts. 19 studies were selected following PRISMA guidelines. Studies were divided into point-based (spectroscopy) or whole field-of-view (imaging) techniques. A fixed-or random-effects model analysis generated pooled sensitivity/specificity for the different modalities, following heterogeneity calculations using the Q statistic. Overall, imaging-based techniques had better pooled sensitivity/specificity (0.90 (CI 0.76-1.03)/0.92 (CI 0.78-1.06)) compared with probe-based techniques (0.84 (CI 0.78-0.89)/0.85 (CI 0.79-0.91)). The use of spectrally resolved diffusely reflected light is a rapid, non-contact technique that confers accuracy in discriminating between normal and malignant breast tissue, and it constitutes a potential IMA tool. |
Issue Date: | 23-May-2023 |
Date of Acceptance: | 16-May-2023 |
URI: | http://hdl.handle.net/10044/1/104951 |
DOI: | 10.3390/cancers15112884 |
ISSN: | 2072-6694 |
Publisher: | MDPI AG |
Journal / Book Title: | Cancers |
Volume: | 15 |
Issue: | 11 |
Copyright Statement: | © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
Publication Status: | Published |
Conference Place: | Switzerland |
Article Number: | ARTN 2884 |
Appears in Collections: | Department of Surgery and Cancer Institute of Global Health Innovation |
This item is licensed under a Creative Commons License