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Assessing the variability in experimental hut trials evaluating insecticide-treated nets against malaria vectors

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Title: Assessing the variability in experimental hut trials evaluating insecticide-treated nets against malaria vectors
Authors: Challenger, J
Nash, RK
Ngufor, C
Sanou, A
Toé, KH
Moore, S
Tungu, PK
Rowland, M
Foster, GM
N'Guessan, R
Sherrard-Smith, E
Churcher, TS
Item Type: Journal Article
Abstract: Experimental hut trials (EHTs) are used to evaluate indoor vector control interventions against malaria vectors in a controlled setting. The level of variability present in the assay will influence whether a given study is well powered to answer the research question being considered. We utilised disaggregated data from 15 previous EHTs to gain insight into the behaviour typically observed. Using simulations from generalised linear mixed models to obtain power estimates for EHTs, we show how factors such as the number of mosquitoes entering the huts each night and the magnitude of included random effects can influence study power. A wide variation in behaviour is observed in both the mean number of mosquitoes collected per hut per night (ranging from 1.6 to 32.5) and overdispersion in mosquito mortality. This variability in mortality is substantially greater than would be expected by chance and should be included in all statistical analyses to prevent false precision of results. We utilise both superiority and non-inferiority trials to illustrate our methodology, using mosquito mortality as the outcome of interest. The framework allows the measurement error of the assay to be reliably assessed and enables the identification of outlier results which could warrant further investigation. EHTs are increasingly playing an important role in the evaluation and regulation of indoor vector control interventions so it is important to ensure that these studies are adequately powered.
Issue Date: 22-Feb-2023
Date of Acceptance: 2-Feb-2023
URI: http://hdl.handle.net/10044/1/102924
DOI: 10.1016/j.crpvbd.2023.100115
ISSN: 2667-114X
Publisher: Elsevier BV
Start Page: 1
End Page: 11
Journal / Book Title: Current Research in Parasitology & Vector-Borne Diseases
Volume: 3
Copyright Statement: © 2023 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Publication Status: Published
Article Number: 100115
Online Publication Date: 2023-02-09
Appears in Collections:Department of Infectious Diseases
School of Public Health

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