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How does the polymer architecture and position of cationic charges affect cell viability?

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Title: How does the polymer architecture and position of cationic charges affect cell viability?
Authors: Correia, JS
Miron Barroso, S
Hutchings, C
Ottaviani, S
Somuncuoğlu, B
Castellano, L
Porter, AE
Krell, J
Georgiou, TK
Item Type: Journal Article
Abstract: Polymer chemistry, composition and molar mass are factors that are known to affect cytotoxicity however the influence of polymer architecture has not been investigated systematically. In this study the influence of the position of the cationic charges along the polymer chain on cytotoxicity was investigated while keeping constant the other polymer characteristics. Specifically, copolymers of various architectures, based on a cationic pH responsive monomer, 2-(dimethylamino)ethyl methacrylate (DMAEMA) and a non-ionic hydrophilic monomer, oligo(ethylene glycol)methyl ether methacrylate (OEGMA) were engineered and their toxicity towards a panel of cell lines investigated. Of the seven different polymer architectures examined, the block-like structures were less cytotoxic than statistical or gradient/tapered architectures. These findings will assist in developing future vectors for nucleic acid delivery.
Issue Date: 21-Jan-2023
Date of Acceptance: 6-Dec-2022
URI: http://hdl.handle.net/10044/1/102139
DOI: 10.1039/d2py01012g
ISSN: 1759-9954
Publisher: Royal Society of Chemistry (RSC)
Start Page: 303
End Page: 317
Journal / Book Title: Polymer Chemistry
Volume: 14
Issue: 3
Copyright Statement: © The Royal Society of Chemistry 2023. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.
Publication Status: Published
Online Publication Date: 2022-12-07
Appears in Collections:Materials
Department of Surgery and Cancer
Faculty of Medicine
Faculty of Natural Sciences

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