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A link between frontal white matter integrity and dizziness in cerebral small vessel disease

Title: A link between frontal white matter integrity and dizziness in cerebral small vessel disease
Authors: Ibitoye, RT
Castro, P
Cooke, J
Allum, J
Arshad, Q
Murdin, L
Wardlaw, J
Kaski, D
Sharp, DJ
Bronstein, AM
Item Type: Journal Article
Abstract: One in three older people (>60 years) complain of dizziness which often remains unexplained despite specialist assessment. We investigated if dizziness was associated with vascular injury to white matter tracts relevant to balance or vestibular self-motion perception in sporadic cerebral small vessel disease (age-related microangiopathy). We prospectively recruited 38 vestibular clinic patients with idiopathic (unexplained) dizziness and 36 age-matched asymptomatic controls who underwent clinical, cognitive, balance, gait and vestibular assessments, and structural and diffusion brain MRI. Patients had more vascular risk factors, worse balance, worse executive cognitive function, and worse ankle vibration thresholds in association with greater white matter hyperintensity in frontal deep white matter, and lower fractional anisotropy in the genu of the corpus callosum and the right inferior longitudinal fasciculus. A large bihemispheric white matter network had less structural connectivity in patients. Reflex and perceptual vestibular function was similar in patients and controls. Our results suggest cerebral small vessel disease is involved in the genesis of dizziness through its effect on balance.
Issue Date: 23-Jun-2022
Date of Acceptance: 21-Jun-2022
URI: http://hdl.handle.net/10044/1/101883
DOI: 10.1016/j.nicl.2022.103098
ISSN: 2213-1582
Publisher: Elsevier
Start Page: 1
End Page: 12
Journal / Book Title: NeuroImage: Clinical
Volume: 35
Copyright Statement: © 2022 Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Publication Status: Published
Article Number: ARTN 103098
Online Publication Date: 2022-06-23
Appears in Collections:Department of Brain Sciences



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