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Sex differences in etiology and short-term outcome in young ischemic stroke patients receiving mechanical thrombectomy

Title: Sex differences in etiology and short-term outcome in young ischemic stroke patients receiving mechanical thrombectomy
Authors: Weber, R
Winezki, E
Katsanos, AH
Cueillette, M
Hajjar, K
Yamac, E
Veltkamp, R
Chapot, R
Item Type: Journal Article
Abstract: BACKGROUND: Although there are well known sex differences in older patients with ischemic stroke receiving acute reperfusion treatments, there is paucity of data in younger patients. METHODS: We investigated sex-related differences in clinical presentation, stroke etiology and short-term outcomes in consecutive young patients with acute ischemic stroke (AIS) below the age of 50 years receiving mechanical thrombectomy (MT) between January 2011 and May 2021 in a tertiary stroke center. RESULTS: We identified a total of 202 young ischemic stroke patients with MT, with 51% being female. Young female AIS patients were significantly younger (39 ± 8 vs. 43 ± 7 years, p < 0.001), and presented with a trend for more severe stroke on admission (median NIHSS 12 vs. 9, p = 0.065), compared to males, respectively. Young female AIS patients had higher rates of embolic strokes of determined or undetermined sources in the anterior circulation, while young male AIS patients suffered more often strokes of arterio-arterial embolism. Complete reperfusion (TICI score 3) was achieved significantly less often in young female AIS patients (69% vs. 83%, p = 0.006), and in-hospital mortality was 2-times higher (5% vs. 2%, p = 0.271) compared to males. CONCLUSIONS: Young female AIS patients receiving MT have higher rates of severe embolic strokes and less often complete reperfusion due to different occlusion sites and stroke etiology compared to males.
Issue Date: 17-Oct-2022
Date of Acceptance: 23-Aug-2022
URI: http://hdl.handle.net/10044/1/101348
DOI: 10.1186/s42466-022-00215-7
ISSN: 2524-3489
Publisher: BioMed Central
Journal / Book Title: Neurological Research and Practice
Volume: 4
Issue: 1
Copyright Statement: © The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
Publication Status: Published
Conference Place: England
Article Number: ARTN 50
Appears in Collections:Department of Brain Sciences

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