Adiposity status close to diagnosis and its association with prostate cancer survival in the UK biobank
File(s)
Published version
Author(s)
Type
Journal Article
Abstract
Substantial evidence links higher adiposity to prostate cancer development. The relationship between adiposity and outcomes after a prostate cancer diagnosis, however, is unclear. This study aimed to investigate the association between adiposity measured close to prostate cancer diagnosis and all-cause and prostate cancer–specific mortality in a prospective cohort study. Cox regression analyses estimated HRs and 95% confidence intervals (CI) for mortality in 3,760 men in the UK Biobank who had first primary prostate cancer and complete data on body mass index (BMI), waist circumference, hip circumference, waist-to-hip ratio (measured up to 2 years before or up to 5 years after diagnosis), and on covariates (diagnosis age and year, smoking, Townsend deprivation index, exercise, sedentary activities, and alcohol). The waist-to-height ratio and body fat percentage (assessed by bioelectrical impedance) were also evaluated as adiposity measures. Each 5-U increment in pre- or post-diagnosis BMI (N = 3,760) was associated with a 30% (95% CI, 1.18–1.44) higher rate of all-cause mortality (deaths = 680), a 33% (95% CI, 1.15–1.52) higher rate of prostate cancer–specific mortality (deaths = 331), and a 28% (95% CI, 1.12–1.47) higher rate of non–prostate cancer mortality (deaths = 347). Positive associations of similar magnitude were observed for separate analyses by pre- and post-diagnosis BMI and for waist and hip circumference, waist-to-hip ratio, waist-to-height ratio, and body fat percentage. Obesity assessed close to prostate cancer diagnosis is associated with higher mortality. More studies are needed to strengthen the evidence and clarify the mechanisms behind the observed associations.
Date Issued
2025-07-16
Date Acceptance
2025-06-25
Citation
Cancer Research Communications, 2025, 5 (7), pp.1155-1170
ISSN
2767-9764
Publisher
American Association for Cancer Research
Start Page
1155
End Page
1170
Journal / Book Title
Cancer Research Communications
Volume
5
Issue
7
Copyright Statement
©2025 The Authors; Published by the American Association for Cancer Research This open access article is distributed under the Creative Commons Attribution 4.0 International (CC BY 4.0) license.
License URL
Identifier
10.1158/2767-9764.CRC-25-0124
Publication Status
Published