A kit-based aluminium-[F-18]fluoride approach to radiolabelled microbubbles
File(s)
Published version
Author(s)
Type
Journal Article
Abstract
The production of 18F-labelled microbubbles (MBs) via the aluminium-[18F]fluoride ([18F]AlF) radiolabelling method and facile inverse-electron-demand Diels–Alder (IEDDA) ‘click’ chemistry is reported. An [18F]AlF-NODA-labelled tetrazine was synthesised in excellent radiochemical yield (>95% RCY) and efficiently conjugated to a trans-cyclooctene (TCO) functionalised phospholipid (40–50% RCY), which was incorporated into MBs (40–50% RCY). To demonstrate the potential of producing 18F-labelled MBs for clinical studies, we also describe a kit-based approach which is amenable for use in a hospital radiopharmacy setting.
Date Issued
2021-10-15
Date Acceptance
2021-10-15
Citation
Chemical Communications, 2021, 57 (88), pp.11677-11680
ISSN
1359-7345
Publisher
Royal Society of Chemistry
Start Page
11677
End Page
11680
Journal / Book Title
Chemical Communications
Volume
57
Issue
88
Copyright Statement
© The Royal Society of Chemistry 2021. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
License URL
Identifier
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000709440700001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Physical Sciences
Chemistry, Multidisciplinary
Chemistry
TUMOR ANGIOGENESIS
CONTRAST AGENT
ULTRASOUND
BR55
Publication Status
Published
Date Publish Online
2021-10-15