The role of osteopontin in the progression of solid organ tumour
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Published version
Author(s)
Type
Journal Article
Abstract
Osteopontin (OPN) is a bone sialoprotein involved in osteoclast attachment
to mineralised bone matrix, as well as being a bone matrix protein, OPN is
also a versatile protein that acts on various receptors which are associated
with different signalling pathways implicated in cancer. OPN mediates
various biological events involving the immune system and the vascular
system; the protein plays a role in processes such as immune response, cell
adhesion and migration, and tumorigenesis. This review discusses the
potential role of OPN in tumour cell proliferation, angiogenesis and
metastasis, as well as the molecular mechanisms involved in these
processes in different cancers, including brain, lung, kidney, liver, bladder,
breast, oesophageal, gastric, colon, pancreatic, prostate and ovarian cancers.
The understanding of OPN’s role in tumour development and progression
could potentially influence cancer therapy and contribute to the
development of novel anti-tumour treatments.
to mineralised bone matrix, as well as being a bone matrix protein, OPN is
also a versatile protein that acts on various receptors which are associated
with different signalling pathways implicated in cancer. OPN mediates
various biological events involving the immune system and the vascular
system; the protein plays a role in processes such as immune response, cell
adhesion and migration, and tumorigenesis. This review discusses the
potential role of OPN in tumour cell proliferation, angiogenesis and
metastasis, as well as the molecular mechanisms involved in these
processes in different cancers, including brain, lung, kidney, liver, bladder,
breast, oesophageal, gastric, colon, pancreatic, prostate and ovarian cancers.
The understanding of OPN’s role in tumour development and progression
could potentially influence cancer therapy and contribute to the
development of novel anti-tumour treatments.
Date Issued
2018-03-02
Date Acceptance
2018-02-05
Citation
Cell Death and Disease, 2018, 9
ISSN
2041-4889
Publisher
Nature Publishing Group
Journal / Book Title
Cell Death and Disease
Volume
9
Copyright Statement
© The Author(s) 2018. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction
in any mediumor format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if
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permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
in any mediumor format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if
changesweremade. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If
material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain
permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Subjects
Science & Technology
Life Sciences & Biomedicine
Cell Biology
CLEAR-CELL CARCINOMA
BREAST-CANCER CELLS
HUMAN HEPATOCELLULAR-CARCINOMA
ENDOTHELIAL GROWTH-FACTOR
HUMAN COLORECTAL-CANCER
GASTRIC-CANCER
LUNG-CANCER
PROSTATE-CANCER
PROGNOSTIC-SIGNIFICANCE
DOWN-REGULATION
Publication Status
Published
Article Number
356