Physical stimuli-responsive vesicles in drug delivery: Beyond liposomes and polymersomes
File(s)
Accepted version
Author(s)
Kauscher, U
Holme, M
Björnmalm, M
Stevens, Molly
Type
Journal Article
Abstract
Over the past few decades, a range of vesicle-based drug delivery systems have entered clinical practice and several others are in various stages of clinical translation. While most of these vesicle constructs are lipid-based (liposomes), or polymer-based (polymersomes), recently new classes of vesicles have emerged that defy easy classification. Examples include assemblies with small molecule amphiphiles, biologically derived membranes, hybrid vesicles with two or more classes of amphiphiles, or more complex hierarchical structures such as vesicles incorporating gas bubbles or nanoparticulates in the lumen or membrane. In this review, we explore these recent advances and emerging trends at the edge and just beyond the research fields of conventional liposomes and polymersomes. A focus of this review is the distinct behaviors observed for these classes of vesicles when exposed to physical stimuli - such as ultrasound, heat, light and mechanical triggers - and we discuss the resulting potential for new types of drug delivery, with a special emphasis on current challenges and opportunities.
Date Issued
2019-01-01
Date Acceptance
2018-10-22
Citation
Advanced Drug Delivery Reviews, 2019, 138, pp.259-275
ISSN
0169-409X
Publisher
Elsevier
Start Page
259
End Page
275
Journal / Book Title
Advanced Drug Delivery Reviews
Volume
138
Copyright Statement
© 2018 Elsevier Ltd. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence http://creativecommons.org/licenses/by-nc-nd/4.0/
Sponsor
Wellcome Trust
Commission of the European Communities
Medical Research Council (MRC)
Identifier
https://www.sciencedirect.com/science/article/pii/S0169409X1830262X?via%3Dihub
Grant Number
098411/Z/12/Z
ERC-2013-CoG-616417
MR/R015651/1
Subjects
Science & Technology
Life Sciences & Biomedicine
Pharmacology & Pharmacy
Physical stimulus
Vesicle
Ultrasound
Thermo-responsive
Light-responsive
Mechano-responsive
Amphiphile
Self-assembly
DECORATED CYCLODEXTRIN VESICLES
ULTRASOUND CONTRAST AGENTS
SUPRAMOLECULAR VESICLES
MOLECULAR RECOGNITION
FOCUSED ULTRASOUND
AMPHIPHILIC CYCLODEXTRINS
EXTRACELLULAR VESICLES
PHOTODYNAMIC THERAPY
PHOTOTHERMAL THERAPY
MEDIATED DELIVERY
Amphiphile
Light-responsive
Mechano-responsive
Physical stimulus
Self-assembly
Thermo-responsive
Ultrasound
Vesicle
Pharmacology & Pharmacy
1115 Pharmacology and Pharmaceutical Sciences
Publication Status
Published
Date Publish Online
2018-10-25