Antibody-mediated protection against respiratory syncytial virus in children
File(s)
Author(s)
Type
Journal Article
Abstract
Respiratory syncytial virus (RSV) is a major global pathogen, causing lower respiratory tract disease in at-risk populations including young children. Antibodies form a crucial layer of protection from RSV disease, particularly in immunologically naïve infants. Such antibodies are derived from the mother via transplacental transfer and breast milk, but may be particularly low in high-risk infants such as those born preterm. Maternally derived antibodies can now be supplemented by the administration of anti-RSV monoclonal antibodies, while a rising wave of maternal and paediatric vaccine strategies are approaching. The implementation of these prophylactics may profoundly decrease the healthcare burden of RSV. In this article, we review the role of antibody-mediated immunity in protecting children from RSV. We focus on maternally derived antibodies as the main source of protection against RSV and study factors that influence the scale of this transfer. The role of passive and active prophylactic approaches in protecting infants against RSV are discussed and knowledge gaps in our understanding of antibody-mediated protection against RSV are identified.
Date Issued
2024-10-01
Date Acceptance
2024-07-31
Citation
European Respiratory Review, 2024, 33 (174)
ISSN
0905-9180
Publisher
European Respiratory Society
Start Page
240106
End Page
240106
Journal / Book Title
European Respiratory Review
Volume
33
Issue
174
Copyright Statement
© The authors 2024 This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions@ersnet.org.
License URL
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/39384305
PII: 33/174/240106
Subjects
Humans
Respiratory Syncytial Virus Infections
Antibodies, Viral
Respiratory Syncytial Virus, Human
Immunity, Maternally-Acquired
Infant
Respiratory Syncytial Virus Vaccines
Infant, Newborn
Female
Child, Preschool
Child
Age Factors
Milk, Human
Risk Factors
Immunization, Passive
Animals
Host-Pathogen Interactions
Publication Status
Published
Coverage Spatial
England
Article Number
240106
Date Publish Online
2024-10-09