Use of zebrafish to study Shigella infection
File(s)dmm032151.full.pdf (4.74 MB)
Published version
Author(s)
Duggan, Gina M
Mostowy, Serge
Type
Journal Article
Abstract
Shigella is a leading cause of dysentery worldwide, responsible for up to 165 million cases of shigellosis each year. Shigella is also recognised as an exceptional model pathogen to study key issues in cell biology and innate immunity. Several infection models have been useful to explore Shigella biology; however, we still lack information regarding the events taking place during the Shigella infection process in vivo. Here, we discuss a selection of mechanistic insights recently gained from studying Shigella infection of zebrafish (Danio rerio), with a focus on cytoskeleton rearrangements and cellular immunity. We also discuss how infection of zebrafish can be used to investigate new concepts underlying infection control, including emergency granulopoiesis and the use of predatory bacteria to combat antimicrobial resistance. Collectively, these insights illustrate how Shigella infection of zebrafish can provide fundamental advances in our understanding of bacterial pathogenesis and vertebrate host defence. This information should also provide vital clues for the discovery of new therapeutic strategies against infectious disease in humans.
Date Issued
2018-02-26
Date Acceptance
2018-02-01
Citation
Disease Models & Mechanisms, 2018, 11 (2)
ISSN
1754-8403
Publisher
Company of Biologists
Journal / Book Title
Disease Models & Mechanisms
Volume
11
Issue
2
Copyright Statement
© 2018. Published by The Company of Biologists Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000426106000011&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Life Sciences & Biomedicine
Cell Biology
Pathology
Antimicrobial resistance
Autophagy
Cytoskeleton
Emergency granulopoiesis
Inflammation
Macrophage
Neutrophil
Septin
Shigella
Zebrafish
NEUTROPHIL EXTRACELLULAR TRAPS
INNATE IMMUNE-RESPONSE
ACTIN-BASED MOTILITY
HOST-DEFENSE
BACTERIAL PEPTIDOGLYCAN
INFLAMMASOME ACTIVATION
HEMATOPOIETIC STEM
CELL-DEATH
AUTOPHAGY
PATHOGENS
Publication Status
Published
Article Number
UNSP dmm032151